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Search Results for " TR-1 "

ターゲット

阻害剤

天然化合物

1747

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T13435	TR antagonist 1		Thyroid hormone receptor(THR)
	TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities.		Thyroid hormone receptor(THR)
T15405	GNE-781		Epigenetic Reader Domain
	GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).		Epigenetic Reader Domain
T10339	Antitrypanosomal agent 1		Parasite
	Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor (IC50: 3.3 μM). Antitrypanosomal agent 1 inhibits glutathione reductase (IC50: 64.8 μM) and T. brucei (EC50: 1 μM).		Parasite
T37173	MPro Inhibitor 11a
	MProinhibitor 11a is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.053 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-i...
T81670	NKG2D-IN-1
	NKG2D-IN-1, also known as compound 21, is an inhibitor of the natural killer group 2D receptor (NKG2D) exhibiting inhibitory concentration 50 (IC50) values of 0.3 µM in NKG2D/MICA TR-FRET assays and 0.7 µM in ULBP6 TR-FR...
T15397	GNE-049		Epigenetic Reader Domain
	GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, respectively).		Epigenetic Reader Domain
T10014	(1α,1'S,4β)-Lanabecestat	(1α,1'S,4β)-AZD3293	Others
	(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzymel (BACE1) inhibitor, and has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively.		Others
T82838	BODIPY TR-X	BODIPY TR-X NHS Ester
	BODIPY TR-X (BODIPY TR-X NHS Ester) is a potent fluorescent dye capable of labeling primary amines (R-NH2) in proteins, amine-modified oligonucleotides, and other amine-containing molecules. This dye exhibits bright, red...
T17149	Tr-PEG2-OH		Others
	Tr-PEG2-OH is a PEG-based PROTAC linker utilized in PROTAC synthesis[1]. It also serves as a non-cleavable 2-unit PEG ADC linker for the synthesis of antibody-drug conjugates (ADCs)[2].		Others
T83956	CELT-133
	CELT-133 is a selective fluorescent antagonist for the hα1A adrenergic receptor, demonstrating complete selectivity towards α1A over α2A receptors, with a Ki of 5 nM and 15% displacement at 1 μM in radioligand binding as...
T81669	NKG2D-IN-2
	NKG2D-IN-2 (compound 47) is an inhibitor of the natural killer group 2D receptor (NKG2D), demonstrating half-maximal inhibitory concentrations (IC50s) of 0.1 µM for NKG2D/MICA and 0.2 µM for ULBP6 in time-resolved fluore...
T83957	CELT-211
	CELT-211 is a potent, selective fluorescent ligand for the h5HT2B serotonin receptor, demonstrating full selectivity over h5HT2A and h5HT2C receptors with a Ki value of 56.3 nM in radioligand binding assays for h5HT2B re...
T83752	Biotin-SRC-1 (676–700) TFA	Biotin-Steroid Receptor Coactivator 1 (676-700)
	Biotin-SRC-1 (676–700), a biotinylated and truncated variant of steroid receptor coactivator 1 (SRC-1), finds application in affinity-based reporter assays such as time-resolved FRET (TR-FRET) and amplified luminescent p...
T79390	Antileishmanial agent-23		Parasite
	Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM. It effectively inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypan...		Parasite
T83952	CoraFluor 1, amine reactive
	CoraFluor 1, an amine-reactive terbium-based compound, serves as a potent donor in time-resolved Förster resonance energy transfer (TR-FRET) assays, including applications in target engagement and ternary complex assessm...
T78697	Keap1-Nrf2-IN-15
	Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence re...
T82903	Bdp tr nhs ester
	Bdp TR NHS Ester is a chemiluminescent coupling agent featuring an extended excited state lifetime, ideal for applications in immunoassays, microscopy, and fluorescence polarization analysis. This compound efficiently an...
T37174	SARS-CoV MPro-IN-1
	MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-in...
T82805	Butaprost free acid
	(R)-Butaprost (free acid) is a prostaglandin E2 (PGE2) analog exhibiting high EP2 receptor subtype selectivity, commonly used to delineate EP receptor expression in human and animal tissues and cells. In 1986, Gardiner i...

Compounds

TR antagonist 1

T13435

Synonym:

Target: Thyroid hormone receptor(THR)

GNE-781

T15405

Synonym:

Target: Epigenetic Reader Domain

Antitrypanosomal agent 1

Target: Epigenetic Reader Domain

(1α,1'S,4β)-Lanabecestat

T10014

Synonym: (1α,1'S,4β)-AZD3293

Target: Others

BODIPY TR-X

T82838

Synonym: BODIPY TR-X NHS Ester

Biotin-SRC-1 (676–700) TFA

T83752

Synonym: Biotin-Steroid Receptor Coactivator 1 (676-700)

Target:

Antileishmanial agent-23

T79390

Synonym:

Target: Parasite

CoraFluor 1, amine reactive

カタログ番号	製品名	別名	ターゲット
T2801	Aristolochic acid A	TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid	Others , NF-κB
	Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort (Aristolochiaceae) family of plants.		Others , NF-κB

天然物製品

Aristolochic acid A

T2801

Synonym: TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid

Target: Others, NF-κB

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-05096	Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 103.6 kDa and the accession number is CAA25527.1.
TMPY-01873	Transferrin Receptor/TFRC Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Transferrin Receptor/TFRC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is AAA61153.1.
TMPY-02294	Transferrin Receptor/TFRC Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Transferrin Receptor/TFRC Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.3 kDa and the accession number is Q62351.
TMPY-01802	C-Kit Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	c-Kit Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57 kDa and the accession number is P05532-1.
TMPY-02271	TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)	Human	E. coli
	Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidat...
TMPY-00112	Tomoregulin-1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	TMEFF1 is a novel transmembrane protein, containing two follisatin domains and an epidermal growth factor-like region. The ectopic expression of TMEFF1 in brain cancer cells resulted in their growth inhibition. That TMEF...
TMPY-05025	Thrombin Receptor Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Thrombin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10.2 kDa and the accession number is A0A024RAP7.
TMPJ-00378	Transferrin Receptor/TFRC Protein, Human, Recombinant (aa 101-760, His)	Human	HEK293 Cells
	Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa). TFRC regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP...
TMPY-05617	Transferrin Receptor/TFRC Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	Transferrin Receptor/TFRC Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is P02786.
TMPY-04509	Osteoprotegerin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Osteoprotegerin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.2 kDa and the accession number is O08712.
TMPY-05169	Peroxiredoxin 2 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	Peroxiredoxin 2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 24.1 kDa and the accession number is Q61171.
TMPY-05262	Osteoprotegerin Protein, Human, Recombinant (hFc)	Human	Baculovirus Insect Cells
	Osteoprotegerin Protein, Human, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 70.3 kDa and the accession number is O00300.
TMPY-01724	Osteoprotegerin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Osteoprotegerin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.3 kDa and the accession number is O00300.
TMPH-00078	Beta-amylase 1, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc)	Arabidopsis thaliana	E. coli
	Beta-amylase activity. Can use p-nitrophenyl maltopentaoside (PNPG5) as substrate only in reduced form. Can play a minor role in the starch degradation and maltose metabolism in chloroplasts during the night. More active...
TMPY-01801	C-Kit Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	c-Kit Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.5 kDa and the accession number is P05532-1.
TMPY-01751	DR3/TNFRSF25 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-05760	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPK-00631	DR3/TNFRSF25 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly e...
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&...
TMPY-02501	CD3D & CD3E Heterodimer Protein, Human, Recombinant	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
TMPY-03878	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
TMPY-04069	Neurotrophin 3 Protein, Human, Recombinant	Human	E. coli
	NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely relate...
TMPY-03958	TGF alpha Protein, Human, Recombinant	Human	E. coli
	The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared...
TMPK-00305	TGFBR1 Protein, Human, Recombinant (mFc & Avi)	Human	HEK293 Cells
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPK-00114	C-Reactive Protein /CRP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate ...
TMPK-00383	ACE2/ACEH Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio...
TMPY-02031	B7-H3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	B7-H3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is Q5ZPR3-1.
TMPY-00699	CD155/PVR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD155/PVR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P15151-1.
TMPY-00586	CLEC-2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	CLEC-2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9JL99-1.
TMPY-00972	FGFR2 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	FGFR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67.6 kDa and the accession number is P21802-1.
TMPY-03762	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.1 kDa and the accession number is P12830-1.
TMPK-01074	CD163 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in ...
TMPY-00915	Serpin A1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Serpin A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is P01009-1.
TMPY-02794	TLR2 Protein, Human, Recombinant (aa 1-587, His)	Human	Baculovirus Insect Cells
	TLR2 Protein, Human, Recombinant (aa 1-587, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 65.5 kDa and the accession number is O60603-1.
TMPK-00176	BAFF/TNFSF13B Trimer Protein, Human, Recombinant (His & Flag)	Human	HEK293 Cells
	B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene.BAFF is a cytokine that belongs to the tumor necrosis factor (...
TMPY-05016	HHLA2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HHLA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.4 kDa and the accession number is Q9UM44-1.
TMPY-04925	CD8 beta Protein, Human, Recombinant, Biotinylated	Human	HEK293 Cells
	CD8 beta Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is P10966-1.
TMPY-04957	PD-L2 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1.
TMPY-00654	ACVR2B Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ACVR2B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.0 kDa and the accession number is Q13705-1.
TMPY-03481	IL-1R2 Protein, Human, Recombinant	Human	HEK293 Cells
	IL-1R2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.4 kDa and the accession number is P27930-1.
TMPY-03363	C-Reactive Protein Protein, Human, Recombinant	Human	HEK293 Cells
	C-Reactive Protein Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23 kDa and the accession number is P02741-1.
TMPY-03383	IL-7 Protein, Human, Recombinant	Human	E. coli
	IL-7 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P13232-1.
TMPK-01151	MXRA8 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Human, Recombinant (His) is expressed in ...
TMPY-01065	GM-CSFR alpha Protein, Human, Recombinant (His)	Human	HEK293 Cells
	GM-CSFR alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36 kDa and the accession number is P15509-1.
TMPY-04966	PCSK9 Protein, Human, Recombinant (D374Y, His)	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1.
TMPY-04970	TIGIT Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	TIGIT Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.2 kDa and the accession number is Q495A1-1.
TMPY-05435	ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is Q15389-1.
TMPY-01037	CSF1R Protein (Met1-Glu512), Human, Recombinant (His)	Human	HEK293 Cells
	CSF1R Protein (Met1-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is P07333-1.
TMPY-03947	CD48 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD48 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is P09326-1.
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