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T67916 |
CYP4A11/CYP4F2-IN-2
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P450
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CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 can be extracted from liver and kidney an... |
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T62452 |
HIV-1 inhibitor-40
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Others
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HIV-1 inhibitor-40 (Compound 4ab) is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) (EC50: 1.9 nM) with no significant acute toxicity in vivo. Orexin receptor antagonist is a highly sensitive inhibitor o... |
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T84947 |
Desethoxy Quetiapine hydrochloride
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O-Desalkylquetiapine |
Others
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Desethoxy quetiapine, an active metabolite of the atypical antipsychotic quetiapine, primarily forms through the action of the cytochrome P450 (CYP) isoform CYP3A5. This compound binds to dopamine D2 receptors with an IC... |
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T36187 |
Celecoxib Carboxylic Acid
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Others
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Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib .1,2It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9.
1.Liu, H., Huang, X., Shen, J., et al.Inhibitory... |
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T36084 |
PKI-179
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Others
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PKI-179 is a potent, orally active compound that functions as a dual PI3K/mTOR inhibitor. It demonstrates IC50 values of 8 nM for PI3K-α, 24 nM for PI3K-β, 74 nM for PI3K-γ, 77 nM for PI3K-δ, and 0.42 nM for mTOR. Additi... |
