Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 can be extracted from liver and kidney and has the potential to treat kidney diseases.
説明 | CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 can be extracted from liver and kidney and has the potential to treat kidney diseases. |
ターゲット&IC50 | CYP4A11:140 nM, 20-HETE:29 nM, CYP4F2:40 nM |
In vitro | CYP4A11/CYP4F2-IN-2 suppresses 20-Hydroxyeicosatetraenoic acid (20-HETE) production from arachidonic acid in human renal microsomes, with an IC50 of 29 nM.[1] |
In vivo |
CYP4A11/CYP4F2-IN-2 (0.03-1 mg/kg; a single p.o.) effectively inhibits renal 20-HETE production in rats in a dose-dependent manner.[1] CYP4A11/CYP4F2-IN-2 (0.5 mg/kg; i.v.) demonstrates a low clearance rate (1430 mL/h/kg), a moderate volume of distribution (763 mL/kg), and short half-life (0.424 h) in mice.[1] CYP4A11/CYP4F2-IN-2 (1 mg/kg; i.v.) exhibits low clearance (226 mL/h/kg), moderate volume of distribution (839 mL/kg), and a half-life of (3.01 h) in SD rats.[1] CYP4A11/CYP4F2-IN-2 (1 mg/kg; p.o.) shows a maximum concentration (623 ng/mL), a half-life of (3.03 h), and high bioavailability (97.7%) in SD rats.[1] |
分子量 | 300.36 |
分子式 | C16H20N4O2 |
CAS No. | 2126874-77-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (74.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CYP4A11/CYP4F2-IN-2 2126874-77-7 Metabolism P450 CYP4A11/CYP4F2IN2 Inhibitor inhibitor inhibit