| T9704 |
1-Ethynylpyrene
|
34993-56-1
|
98%
|
|
|
1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).
|
| TN1482 |
Chamaechromone
|
93413-00-4
|
98%
|
|
|
Chamaechromone is a natural product isolated from the roots of Stellera chamaejasme L.. Chamaechromone has anti-HBV and insecticidal activity.
|
| T36125 |
Tienilic Acid
|
40180-04-9
|
98%
|
|
|
Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity
|
| T67916 |
CYP4A11/CYP4F2-IN-2
|
2126874-77-7
|
98%
|
|
|
CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CY...
|
| T19783 |
Dehydroabiethylamine
|
1446-61-3
|
98%
|
|
|
Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular ch...
|
| T5582 |
β-Apo-8'-carotenal
|
1107-26-2
|
|
|
|
β-Apo-8'-carotenal (Apocarotenal) is a carotenoid found in spinach and citrus fruits. Apocarotenal is used in fat-based food (margarine, sauces, salad dressing),...
|
| T8182L |
Guan-fu base A hydrochloride(1394-48-5 free base)
|
618094-85-2
|
|
|
|
Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monke...
|
| T3668 |
Galangin
|
548-83-4
|
|
|
|
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
|
| T21425 |
Mephenytoin
|
50-12-4
|
|
|
|
Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.
|
| T19526 |
Pradefovir mesylate
|
625095-61-6
|
|
|
|
Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.
|
| T1443 |
Memantine hydrochloride
|
41100-52-1
|
|
|
|
Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparki...
|
| T8079 |
α-Terpinyl acetate
|
80-26-2
|
|
|
|
α-Terpinyl acetate is a natural compound found in several essential oils, is a flavouring agent.
|
| TQ0217 |
Gomisin G
|
62956-48-3
|
|
|
|
Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
|
| T9328 |
Ellagic Acid Dihydrate
|
133039-73-3
|
|
|
|
Ellagic Acid Dihydrate inhibit the CYP1A1-dependent activation of benzo[a]pyrene.
|
| T7370 |
Talarozole
|
201410-53-9
|
|
|
|
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5....
|
| TN6848 |
Piperonylic acid
|
94-53-1
|
|
|
|
Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinna...
|
| T10335 |
Antihistamine-1
|
1186430-60-3
|
100%
|
|
|
Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 ...
|
| T0179 |
Ticagrelor
|
274693-27-5
|
100%
|
|
|
Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic ...
|
| T1597 |
Proadifen hydrochloride
|
62-68-0
|
100%
|
|
|
Proadifen hydrochloride (RP-5171) is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.
|
| T7725 |
Albaconazole
|
187949-02-6
|
100%
|
|
|
Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, s...
|
