|
T2678 |
LB42708
|
|
Transferase
|
|
|
|
T38050 |
CP-609754
|
|
Transferase
|
|
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 n... |
|
T17102 |
Tipifarnib (S enantiomer)
|
Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer |
Transferase
|
|
Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM). |
|
T27773L |
L-739750 2HCl
|
L-739750 2HCl(160141-08-2 Free base) |
Transferase
|
|
L-739750 2HCl is a potent inhibitor of peptidomimetic farnesyltransferase, a novel pseudopeptide mimetic with potential anticancer activity. |
|
T2700 |
FTI-277 hydrochloride
|
FTI 277 HCl |
Apoptosis
,
Transferase
,
Ras
|
|
FTI-277 hydrochloride (FTI 277 HCl) is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I. |
|
T10512 |
Prenyl-IN-1
|
|
Transferase
|
|
Prenyl-IN-1 is a potent and selective prenylation inhibitor of geranylgeranyltransferase or farnesyltransferase.Prenyl-IN-1 shows anti-oxidative stress effects in a Parkinson's model. Prenyl-IN-1 showed anti-oxidative st... |
|
T24351 |
L 731735
|
L-731,735,L731735,L-731735,L731,735,L 731,735 |
|
|
L 731735 is a farnesyltransferase inhibitor. |
|
T24273 |
Kurasoin B
|
Kurasoin-B |
|
|
Kurasoin B is an inhibitor of protein farnesyltransferase. |
|
T27773 |
L-739750
|
|
|
|
L-739,750 is an inhibitor (FTI) of peptidomimetic farnesyltransferase. |
|
T24350 |
L 731734
|
L-731,734,L 731,734,L731734,L731,734,L-731734 |
|
|
L 731734 is a farnesyltransferase inhibitor. |
|
T71375 |
FTI-2600
|
|
|
|
FTI-2600 is a farnesyltransferase inhibitor. |
|
T15770 |
(Rac)-CP-609754
|
LNK754 |
Influenza Virus
|
|
LNK754 is a farnesyltransferase inhibitor. It is used for the treatment of cancer and Alzheimer's disease. |
|
T25939 |
Pepticinnamin E
|
|
|
|
Pepticinnamin E is a naturally occurring bisubstrate farnesyltransferase inhibitor. |
|
T70372 |
FTI-249
|
|
|
|
FTI-249 is a Farnesyltransferase inhibitor, which potently inhibited FTase (IC50 = 100–200 nM). |
|
T40331 |
Ftase inhibitor III
|
|
|
|
Ftase Inhibitor III, derived from a phenotypic screen, functions as an anion-dependent inhibitor of Farnesyltransferase. |
|
T70554 |
Chaetomellic acid A
|
|
|
|
Chaetomellic acid A is a potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and I... |
|
T11331L |
FTI 276
|
|
Others
|
|
FTI-276 is an inhibitor of protein farnesyltransferase (PFT) (IC50s: 0.9 and 0.5 nM for Plasmodium falciparum and human). |
|
T70405 |
L-744832
|
|
|
|
L-744832, also known as L-744,832, is a potent Farnesyltransferase inhibitor with potential anticancer activity. |
|
T26469 |
A-176120
|
|
|
|
A-176120 is a potent farnesyl pyrophosphate (FPP) analogues, it selectively inhibits farnesyltransferase. It has anti-angiogenic potential and may reduce H-ras NIH3T3 tumour growth. |
|
T68923 |
FTI-2628
|
|
|
|
FTI-2628 is a novel inhibitor of protein farnesyltransferase (FT), inhibiting the growth of P. falciparum in red blood cells and suppressing parasitemia. |
|
T74976 |
Antifungal agent 46
|
|
Ras
|
|
Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1]. |
|
T69710 |
LB42908
|
|
|
|
LB42908 is a highly potent Ras farnesyltransferase inhibitor(IC(50)=0.9 nM against H-Ras and 2.4 nM against K-Ras) with potential anticancer activity. |
|
T15353 |
FTI-2153
|
|
Others
|
|
FTI-2153 is a potent and highly selective farnesyltransferase (FTase) inhibitor (IC50: 1.4 nM). FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. |
|
T68227 |
BMS-214662 HCl
|
|
|
|
BMS-214662 is a Farnesyltransferase inhibitor , is also a nonsedating benzodiazepine derivative with potential antineoplastic activity. BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnes... |
|
T64101 |
FTI-2153 TFA
|
|
|
|
FTI-2153 TFA is a highly selective and potent inhibitor of the farnesyltransferase (FTase) enzyme (IC50: 1.4 nM). The inhibition activity was more than 3000 times that of Rap1A protein processing. |
|
T69993 |
BIM-46068
|
|
|
|
BIM-46068 is a potent and specific inhibitor of human farnesyltransferase. In regard to a panel of cell lines, using the Compare analysis to determine the Pearson coefficient correlation, the anti-proliferative spectrum ... |
|
T41212 |
FTI 277
|
|
|
|
FTI 277 is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10μM respectively) and disrupts constitutive H-R... |
|
T62675 |
FTI-277
|
|
|
|
FTI-277 is a farnesyltransferase FTase inhibitor and a potent Ras CAAX peptide mimetic.FTI-277 inhibits H-Ras and K-Ras signaling and inhibits hepatitis delta virus (HDV) infection. |
|
T69994 |
BIM-46050
|
|
|
|
BIM-46050 is a potent and specific inhibitor of human farnesyltransferase. BIM-46050 is free acidic form of BIM-46068. The IC50 values for in vitro inhibition of human brain FTase indicate that BIM-46050 and the ester fo... |
|
T70287 |
BMS-186511
|
|
|
|
BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from m... |
