|
T1101 |
Minocycline hydrochloride
|
Minocycline HCl |
HIF/HIF Prolyl-Hydroxylase
,
Antibacterial
,
Antibiotic
|
|
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor... |
|
T37746 |
N-phenylacetyl-L-Homoserine lactone
|
|
Others
|
|
N-phenylacetyl-L-Homoserine lactone attenuates the group sensing of the pathogen Acinetobacter baumannii and can be used to study bacterial infections. |
|
T61042 |
TBT1
|
|
|
|
TBT1 is a MsbA ATPase stimulator and an LPS transport inhibitor in Acinetobacter strains. The EC50 value of TBT1 stimulated ATPase activity is 13 μM. TBT1 is a first-generation inhibitor of the MsbA transporter [1]. |
|
T11125 |
Durlobactam sodium salt
|
ETX2514 sodium salt |
Antibacterial
|
|
Durlobactam sodium salt (ETX2514 sodium salt) is an inhibitor of β-lactamase with IC50 values of 4 nM, 14 nM, and 190 nM for Class A KPC-2, Class C AmpC, and Class D OXA-24, respectively. Durlobactam sodium salt can be u... |
|
T1569 |
Tigecycline
|
GAR-936 |
ribosome
,
Antibacterial
,
Antibiotic
,
Autophagy
|
|
Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome co... |
|
T14492 |
BAL-30072
|
|
Others
|
|
BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively[1][2]. BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against m... |
|
T39983 |
SPR206 acetate
|
|
|
|
SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetat... |
|
T75279 |
Tigecycline tetramesylate
|
|
|
|
Tigecycline tetramesylate (GAR-936 tetramesylate), a broad-spectrum glycylcycline antibiotic, exhibits a mean inhibitory concentration (MIC) for E. coli (MG1655 strain) of approximately 125 ng/mL [1]. For Acinetobacter b... |
|
T68438 |
APO-6619
|
|
|
|
APO-6619 is an iron chelator which was shown to inhibit growth of the following bacterial strains: Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. AP... |
|
T39296 |
DS86760016
|
|
|
|
DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and ... |
|
T74866 |
Antibacterial agent 116
|
|
|
|
Antibacterial agent 116, a benzophenone-containing salicylanilide compound, exhibits potent antibacterial activity by inhibiting peptidoglycan formation. It is employed as a photoaffinity probe to label Acinetobacter bau... |
|
T74341 |
Antibacterial agent 71
|
|
|
|
The compound demonstrates enhanced potency against wild-type (WT) strains of Escherichia coli, Acinetobacter baumannii, and Burkholderia cenocepacia, showing significant improvements of up to (>128-fold) due to increased... |
|
T73798 |
Colistin
|
|
|
|
Colistin (Polymyxin E), a polypeptide antibiotic with oral activity, exhibits strong efficacy against a range of Gram-negative rod-shaped bacteria, such as multidrug-resistant Pseudomonas aeruginosa, Acinetobacter bauman... |
|
T79240 |
DNA gyrase B-IN-2
|
|
|
|
DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE pathogens. The compound exhibits potent nanomolar-range inhibition ... |
|
T12991 |
SPR206
|
|
Others
|
|
SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen. |
