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T7378 |
BRD9539
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Histone Methyltransferase
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BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM |
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T1923 |
BRD4770
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Histone Methyltransferase
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BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence. |
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T37450 |
SSK1
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p38 MAPK
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SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in... |
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T77767L1 |
GLF16 HCl
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Others
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GLF16 HCl is a fluorophore-coupled Sudan Black B analog that allows rapid detection, isolation and real-time tracking of senescent cells by fluorescence microscopy and flow cytometry. |
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T36884 |
BM-1244
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BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM[1]. |
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T76563 |
FOXO4-DRI
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FOXO4-DRI, a cell-permeable peptide antagonist, inhibits the interaction between FOXO4 and p53. It functions as a senolytic peptide, promoting apoptosis in senescent cells [1]. |
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T77767L |
GLF16 FA
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GLF16 FA is a hydrophilic fluorescent SBB analogue for rapid detection of senescent cells using flow cytometry and live cell sorting. |
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T77767 |
GLF16
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GLF16 is a hydrophilic fluorescent SBB analog and robustly identifies senescence. It enables the use of flow cytometry and live cell sorting for rapid senescent cell detection. GLF16 is suitable for in vivo identificatio... |
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T74867 |
UBX1325
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UBX1325, a Bcl-xL inhibitor, enhances apoptosis in senescent cells, serving as an effective anti-aging agent. It holds potential for age-related eye disease research, including diabetic macular oedema (DME), age-related ... |
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T35993 |
Epitalon (acetate)
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Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalo... |
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T38043 |
Resolvin E4
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Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE inte... |
