p38 MAPK

p38 MAPKs (α, β, γ, and δ) are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/6, the p38 MAPK kinases. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. p38 MAPK is involved in regulation of HSP27, MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and several transcription factors including ATF-2, Stat1, the Max/Myc complex, MEF-2, Elk-1, and indirectly CREB via activation of MSK1.

Cat. No.	製品名	CAS No.	Purity
T3390	Obacunone	751-03-1	98%
T3390	Obacunone has cytotoxicity in androgen-dependent human prostate Y cells. Obacunone exerts an antivirulence effect on S. Typhimurium and may serve as a lead compo...
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T4645	TA-01	1784751-18-3	98%
T4645	TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.
T4S2063	Tetrahydrocoptisine	4312-32-7	98%
T4S2063	1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
T12979	BI-3406	2230836-55-0	98%
T12979	BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
T14381	AZD7624	1095004-78-6	98%
T14381	AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.
T77621	Z16078526	852222-94-7	98%
T77621	Z16078526 induces endogenous Ucp1 expression, promotes p38 MAPK phosphorylation and lipolysis in primary mouse brown adipocytes. Z16078526 activates thermogenic ...
TN1711	Gossypetin	489-35-0	98%
TN1711	Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signal...
TN6814	2-Aminooctadecane-1,3,4-Triol	13552-11-9	98%
TN6814	Phytosphingosine is a natural product.
T11943	MAPK13-IN-1	229002-10-2	98%
T11943	MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).
T6380	AMG 900	945595-80-2	98%
T6380	AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases ...
T63644	Exarafenib	2639957-39-2	98%
T63644	Exarafenib is a potent and orally available pan-RAF inhibitor.Exarafenib has antitumor activity and acts by inhibiting downstream MAPK pathway signaling.Exarafen...
T4S2326	Cornuside	131189-57-6	98%
T4S2326	1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human en...
T4646	TA-02	1784751-19-4	98%
T4646	TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.
TN3209	3′,4′,7-Trihydroxyflavone	2150-11-0	98%
TN3209	3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
T6S0525	Farrerol	24211-30-1	98%
T6S0525	1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection an...
T2513	VX-702	745833-23-2	98%
T2513	VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than p38β. VX-702 is a small molecule investigational oral anti-cytokine...
TN1448	(-)-Bornyl acetate	5655-61-8	98%
TN1448	(-)-Bornyl acetate is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal activity. (-)-Bornyl ...
T4034	Solamargine	20311-51-7	98%
T4034	Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth...
T3S0209	Vincristine	57-22-7	98%
T3S0209	Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...