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T2112 |
Fexinidazole
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HOE 239 |
Others
,
Parasite
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Fexinidazole (HOE 239) is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologica... |
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T1110 |
Meclizine dihydrochloride
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Meclozine dihydrochloride,NSC28728,Meclizine 2HCl |
Apoptosis
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Histamine Receptor
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Meclizine dihydrochloride (NSC28728) is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. |
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T21281 |
Zolamide
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CL 5343,Tio-urasin,5-Amino-TDSNH2 |
Others
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Zolamide (CL 5343) may be used to prevent altitude sickness and reduce the symptoms. |
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T3282 |
Alimemazine hemitartrate
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Alimemazine Tartrate,Methylpromazine Tartrate,Trimeprazine tartrate,Trimeprazine hemitartrate |
Others
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Alimemazine hemitartrate (Trimeprazine hemitartrate) is aphenothiazine derivative that is used as an antipruritic. It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. |
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T40652 |
Meclizine
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Meclozine |
Histamine Receptor
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Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ... |
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T33278 |
Melarsoprol
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Melarsoprolum,RP 3854,RP3854,RP-3854 |
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Melarsoprol, an organoarsenic compound, can be used to treat trypanosomiasis (human African sleeping sickness). |
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T71685 |
NEU-1953
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NEU-1953 is a potential candidate for sleeping sickness. |
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T28011 |
Megazol
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CL 64855,CL-64855,CL64855 |
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Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping si... |
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T61832 |
HCAI/II-IN-3
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hCAI/II-IN-3 (compound 5b) is a highly effective dual inhibitor of hCA I/II enzymes. It exhibits Ki values of 51.25, 13.15, and 42.18 nM for hCA I, hCA II, and hCA Ⅸ, respectively. hCAI/II-IN-3 demonstrates anti-hypoxic ... |
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T60351 |
Acetazolamide sodium
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OT-302 sodium |
Carbonic Anhydrase
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Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and alt... |
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T61635 |
HCAI/II-IN-4
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hCAI/II-IN-4 (compound 6d) is a powerful inhibitor of both hCA I and hCA II enzymes, with Ki values of 16.95 nM and 15.22 nM, respectively. It demonstrates inhibitory activity against hCA IX with a Ki value of 27.04 nM. ... |
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T69012 |
Cinnarizine clofibrate
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Cinnarizine clofibrate is a calcium channel protein inhibitor as well as an antihistamine channel blocker. The compound is a drug derivative of piperazine. Cinnarizine is used for the control of vomiting due to motion si... |
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T61282 |
HCAI/II-IN-2
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|
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hCAI/II-IN-2 (compound 2b) is a highly effective dual inhibitor of human carbonic anhydrase I and II (hCA I/II), with Ki values of 40.97 nM, 15.15 nM, and 61.88 nM for hCA I, hCA II, and hCA IX, respectively. With its an... |
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T35904 |
O-11
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O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the pr... |
