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Search Results for " ubiquitinated "

ターゲット

3

阻害剤

10

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T21854 Proteasome inhibitor IX PS-IX,AM114 Proteasome
Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c...
T60487 DDO-7263 Nrf2
DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 is a potent Nrf2 activator th...
T73782 Prostaglandin J2
Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. I...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-02521 HIST3H2A Protein, Human, Recombinant Human E. coli
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPH-01684 MAP1LC3C Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also p...
TMPH-03758 TSG101 Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). M...
TMPH-01273 TRIP12 Protein, Human, Recombinant (His & Myc) Human E. coli
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein a...
TMPJ-01325 TOLLIP Protein, Human, Recombinant (His) Human E. coli
Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). ...
TMPH-02300 RAD23A Protein, Human, Recombinant (His) Human E. coli
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chain...
TMPY-02211 USP5 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Ubiquitin carboxyl-terminal hydrolase 5, also known as Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin-specific-processing protease 5, ISOT and USP5, is a member of the peptidase C19 famil...
TMPH-01621 BRCC3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes...
TMPH-01259 AMFR Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01260 AMFR Protein, Human, Recombinant (hFc) Human HEK293 Cells
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...