Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity(IC50 = 1.49 μM).
説明 | Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity(IC50 = 1.49 μM). |
ターゲット&IC50 | 20S proteasome:1 μM |
In vitro | AM114 exhibits potent activity against p53+/+ cells in colony formation assay, with an IC50 value of 0.6 μM[2]. AM114 treatment inhibits the chymotrypsin-like activity of the 20S proteasome in vitro, leading to a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells[2]. In HCT116 p53+/+ cells, AM114(0.1-10 μM) treatment causes a loss of cell survival in the p53+/+ and p53-/- cells by approximately 70 and 20%, respectively at a concentration of 1 μM[2]. |
別名 | PS-IX, AM114 |
分子量 | 377.01 |
分子式 | C20H21B2NO5 |
CAS No. | 856849-35-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.25 mg/mL (16.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Proteasome inhibitor IX 856849-35-9 Proteases/Proteasome Ubiquitination Proteasome acid chymotrypsin-like EGCG 20S p53 inhibit PS-IX ubiquitinated cytotoxic AM114 AM 114 Chalcone AM-114 Inhibitor boronic Anticancer inhibitor