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Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T7369L Gemigliptin Tartrate(911637-19-9 free base) 1374639-74-3 98%
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 n...
T26754 BC-23 6298-15-3 98%
BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity.BC-23 inhibits the CT-L activity of the proteasome and is used in th...
T36902 RA375 98%
RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy aga...
T2493 PD 151746 179461-52-0 98%
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0...
T3359 Aprotinin 9087-70-1 98%
Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, ch...
T7814 Alloxan monohydrate 2244-11-3
Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.
T2470 MDL-28170 88191-84-8
MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.
T6941 PI-1840 1401223-22-0 100%
PI-1840(IC50 = 27 nM)is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postg...
T7133 Anagliptin 739366-20-2 100%
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.
T2296 Trelagliptin succinate 1029877-94-8 100%
Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2...
T6999 Teneligliptin hydrobromide 906093-29-6 100.00%
Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, r...
T12079 ML604440 1140517-08-3 95.24%
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.
T8350 TPCK 402-71-1 96.77%
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
T21617 MG-115 133407-86-0 97.12%
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifi...
T67852 Linagliptin Methyldimer 1418133-47-7 97.23%
Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.
T16169 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 4272-74-6 97.44%
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-a...
T7854 Bortezomib-pinanediol 205393-22-2 97.5%
Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.
T6432 Calpeptin 117591-20-5 97.52%
Calpeptin is a potent, cell-permeable calpain inhibitor.
T13858 RA190 1617495-03-0 97.69%
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
TN1262 3-Feruloylquinic acid 1899-29-2 97.83%
3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
Gemigliptin Tartrate(911637-19-9 free base)
T7369L
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 n...
BC-23
T26754
BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity.BC-23 inhibits the CT-L activity of the proteasome and is used in th...
RA375
T36902
RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy aga...
PD 151746
T2493
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0...
Aprotinin
T3359
Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, ch...
Alloxan monohydrate
T7814
Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.
MDL-28170
T2470
MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.
PI-1840
T6941
PI-1840(IC50 = 27 nM)is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postg...
Anagliptin
T7133
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.
Trelagliptin succinate
T2296
Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2...
Teneligliptin hydrobromide
T6999
Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, r...
ML604440
T12079
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.
TPCK
T8350
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
MG-115
T21617
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifi...
Linagliptin Methyldimer
T67852
Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
T16169
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-a...
Bortezomib-pinanediol
T7854
Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.
Calpeptin
T6432
Calpeptin is a potent, cell-permeable calpain inhibitor.
RA190
T13858
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
3-Feruloylquinic acid
TN1262
3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
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