AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Cat. No.	製品名	CAS No.	Purity
T5576	YKL-06-061	2172617-15-9	98%
T5576	YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
T13173	TMPA	1258275-73-8	98%
T13173	TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.
T13354	Xanthoangelol	62949-76-2	98%
T13354	Xanthoangelol, which can be extracted from Angelica keiskei, inhibits obesity-induced inflammatory responses.Xanthoangelol has antimicrobial activity, inhibits m...
T5793	Britannin	33627-28-0	98%
T5793	Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.
T4S0800	Demethyleneberberine	25459-91-0	98%
T4S0800	Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
T41162	ZLN 024 hydrochloride	1883548-91-1	98%
T41162	ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
T16099	MK8722	1394371-71-1	98%
T16099	MK8722 is an effective and systemic activator of pan-AMPK.
T7362	O-304	1261289-04-6	98%
T7362	O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
T2750	Ginkgolide C	15291-76-6	98%
T2750	Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
TN6751	1-HEXACOSANOL	506-52-5	98%
TN6751	Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
T2978	Mogroside V	88901-36-4	98%
T2978	Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
T10789	Chitosan oligosaccharide	148411-57-8	98%
T10789	Chitosan oligosaccharide, an oligomer of β-(1→4)-linked D-glucosamine, activates AMPK and inhibits inflammatory signaling pathways.
TP2312	MOTS-c(Human) Acetate（1627580-64-6 free）	TP2312	98%
TP2312	MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and ex...
T6291	WZ4003	1214265-58-3	98%
T6291	WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 othe...
T60122	Aldometanib	2904601-67-6	98%
T60122	Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AM...
T3S0195	Nootkatone	4674-50-4	98%
T3S0195	1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent o...
TN2097	Pomolic acid	13849-91-7	98%
TN2097	Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
T24626	PF-249	1467059-70-6	98%
T24626	PF-249 is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.
T60128	N,N-Didesethyl Sunitinib Hydrochloride	873077-70-4	98%
T60128	N,N-Didesethyl Sunitinib Hydrochloride is a potent AMPK inhibitor with IC50 of 393 nM and 141 nM for AMPKα1 and AMPK2,respectively.
T9010	IMM-H007	1221412-23-2	98%
T9010	IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression