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AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T13173 TMPA 1258275-73-8 98%
TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.
T14149 AICAR phosphate 681006-28-0 98%
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose ...
T41162 ZLN 024 hydrochloride 1883548-91-1 98%
ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
T60675L AMPK activator 2 hydrochloride( 2410961-69-0 Free base) 98%
AMPK activator 2 hydrochloride is a fluoroguanidine-containing derivative that up-regulates the AMPK signaling pathway and down-regulates mTOR/4EBP1/p70S6K.AMPK ...
T7362 O-304 1261289-04-6
O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
T2750 Ginkgolide C 15291-76-6
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
TN6751 1-HEXACOSANOL 506-52-5
Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
T2978 Mogroside V 88901-36-4
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
T10789 Chitosan oligosaccharide 148411-57-8
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signal...
T1453 Phenformin hydrochloride 834-28-6
Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
TP2312 MOTS-c(Human) Acetate(1627580-64-6 free) 100%
MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and ex...
T6291 WZ4003 1214265-58-3 100%
WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 othe...
T73350 BAY-3827 2377576-35-5 100%
BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, showing antiproliferative activity in an androgen-dependent prostate cancer ...
T60122 Aldometanib 2904601-67-6 100%
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AM...
TN2097 Pomolic acid 13849-91-7 96.84%
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
T24626 PF-249 1467059-70-6 97.02%
PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.
T60128 N,N-Didesethyl Sunitinib Hydrochloride 873077-70-4 97.1%
N,N-Didesethyl Sunitinib Hydrochloride is a potent AMPK inhibitor with IC50 of 393 nM and 141 nM for AMPKα1 and AMPK2,respectively.
T0740 Metformin hydrochloride 1115-70-4 97.53%
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the...
T9010 IMM-H007 1221412-23-2 97.73%
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression
T20029 Buformin hydrochloride 1190-53-0 97.83%
Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from t...
TMPA
T13173
TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.
AICAR phosphate
T14149
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose ...
ZLN 024 hydrochloride
T41162
ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
T60675L
AMPK activator 2 hydrochloride is a fluoroguanidine-containing derivative that up-regulates the AMPK signaling pathway and down-regulates mTOR/4EBP1/p70S6K.AMPK ...
O-304
T7362
O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
Ginkgolide C
T2750
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
1-HEXACOSANOL
TN6751
Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
Mogroside V
T2978
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema...
Chitosan oligosaccharide
T10789
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signal...
Phenformin hydrochloride
T1453
Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
MOTS-c(Human) Acetate(1627580-64-6 free)
TP2312
MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and ex...
WZ4003
T6291
WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. It is no significant inhibition on 139 othe...
BAY-3827
T73350
BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, showing antiproliferative activity in an androgen-dependent prostate cancer ...
Aldometanib
T60122
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AM...
Pomolic acid
TN2097
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
PF-249
T24626
PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.
N,N-Didesethyl Sunitinib Hydrochloride
T60128
N,N-Didesethyl Sunitinib Hydrochloride is a potent AMPK inhibitor with IC50 of 393 nM and 141 nM for AMPKα1 and AMPK2,respectively.
Metformin hydrochloride
T0740
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the...
IMM-H007
T9010
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression
Buformin hydrochloride
T20029
Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from t...
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