Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 18,000 | |||
5 mg | 在庫あり | ¥ 43,500 | |||
10 mg | 在庫あり | ¥ 68,000 | |||
25 mg | 在庫あり | ¥ 136,000 | |||
50 mg | 在庫あり | ¥ 194,000 | |||
100 mg | 在庫あり | ¥ 268,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 51,000 |
説明 | IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression |
In vitro | IMM-H007 (H007) significantly inhibits monocyte adhesion to endothelial cells and its transendothelial migration.?Mechanistically, H007 markedly represses TNFα-induced IκBα degradation and NF-κB nuclear translocation, therefore leading to NF-κB-mediated inflammatory suppression.?Moreover, another inflammatory signaling JNK/c-Jun, which is always co-activated with NF-κB in response to pro-inflammatory stimuli, is also found to be restrained by H007 through reducing its phosphorylation status.?H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. |
分子量 | 485.45 |
分子式 | C22H23N5O8 |
CAS No. | 1221412-23-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (60.91 mM)
You can also refer to dose conversion for different animals. 詳細
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IMM-H007 1221412-23-2 Chromatin/Epigenetic Others PI3K/Akt/mTOR signaling AMPK JNK Nuclear factor-κB WS 070117 IMM H007 AP-1 inflammatory WS070117 inhibit atherosclerosis Transforming growth factor beta receptors Activator Protein 1 cardiac fibrosis IMM-H 007 JNK/c-Jun IMMH007 IMM-H-007 NF-κB Nonalcoholic fatty liver disease NAFLD WS-070117 TGF-β Receptor AMP-activated protein kinase Nuclear factor-kappaB Inhibitor inhibitor