BTK

Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B cell development.

Cat. No.	製品名	CAS No.	Purity
T5138	BMS-986142	1643368-58-4	98%
T5138	BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).
T14692	BMX-IN-1	1431525-23-3	98%
T14692	BMX-IN-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM...
T36287	Pirtobrutinib	2101700-15-4	98%
T36287	Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inh...
T9705	TL-895	1415823-49-2	98%
T9705	TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and...
T73549	RSH-7	2764609-97-2	98%
T73549	RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptos...
T73463	NX-2127	2416131-46-7	98%
T73463	NX-2127 is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the pro...
T73334	Larotinib	1438072-11-7	98%
T73334	Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.
T13564	AZ7550	1421373-99-0	98%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T4268	CHMFL-BMX-078	1808288-51-8	98%
T4268	CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
T3024	Avitinib	1557267-42-1	98%
T3024	Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potent...
T17220	Vecabrutinib	1510829-06-7	98%
T17220	Vecabrutinib is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.
T5407	Branebrutinib	1912445-55-6	98%
T5407	BMS986195 is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK...
T9408	N-piperidine Ibrutinib	330785-90-5	98%
T9408	N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively[1]. N-piperidine Ibrutinib can be used as a...
T67881	Acalabrutinib enantiomer	1952316-43-6	98%
T67881	Acalabrutinib enantiomer is a chemical compound that belongs to the class of Bruton’s tyrosine kinase (BTK) inhibitors. Acarabitinib enantiomers can be used in t...
T16157	MT-802	2231744-29-7	98%
T16157	MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).
T2603	Spebrutinib	1202757-89-8	98%
T2603	Spebrutinib is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity.
T6078	Saracatinib	379231-04-6	98%
T6078	Saracatinib (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.
T4387	Evobrutinib	1415823-73-2	98%
T4387	Evobrutinib, also known as M-2951 and MSC-2364447C, is a highly selective inhibitor of the Bruton's tyrosine kinase (BTK), which is important in the development ...
T13447	(R)-Zanubrutinib	1691249-44-1	98%
T13447	(R)-Zanubrutinib is a selective inhibitor of Bruton tyrosine kinase (BTK).
T2302	CNX-774	1202759-32-7	98%
T2302	CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).