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Fatty Acid Synthase

Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.Its main function is to catalyze the synthesis of palmitate (C16:0, a long-chain saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of NADPH.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T14298 Rimiducid 195514-63-7 98%
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
T27307L Fasnall HCl 98%
Fasnall HCl is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall HCl also shows potent anti-tumor activity in the MMTV-Neu model ...
T6832 Fatostatin hydrobromide 298197-04-3 98%
Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
T1426 Pyrazinamide 98-96-4 98%
Pyrazinamide, an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.
T36841 IPI-9119 1346564-56-4 98%
IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
T27307 Fasnall 929978-58-5 98%
Fasnall is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) br...
T21724L Fas C-Terminal Tripeptide Acetate T21724L 98%
Fas C-Terminal Tripeptide Acetate shows inhibitory activity of Fas/FAP-1 binding.
T3S1701 Dihydrocurcumin 76474-56-1 98%
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and pr...
T7947 FT113 1630808-89-7 98%
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
TN1803 Isoscoparin 20013-23-4 98%
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
T5S0246 Pseudoprotodioscin 102115-79-7 98%
1. Pseudoprotodioscin has moderate cytotoxicity.
TN1440 Beta-Hydroxyisovalerylshikonin 7415-78-3 98%
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
T11557 FASN-IN-3 2097262-60-5 98%
FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
T11267 FASN-IN-1 1808260-84-5 98%
T3121 Betulin 473-98-3 98%
Betulin (lup-20(29)-ene-3β, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it forms up to 30...
T9732 VY-3-135 1824637-41-3 98%
VY-3-135 is a metastasis inhibitor and an acetyl-​CoA synthetase 2 (ACSS2) modulator.
T3324 Lycorine 476-28-8 98%
Lycorine inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T2468 A-769662 844499-71-4 98%
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
T10656 Trans-C75 191282-48-1 98%
trans-C75 is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).
T10657 C75 218137-86-1 98%
C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).
Rimiducid
T14298
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affin...
Fasnall HCl
T27307L
Fasnall HCl is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall HCl also shows potent anti-tumor activity in the MMTV-Neu model ...
Fatostatin hydrobromide
T6832
Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
Pyrazinamide
T1426
Pyrazinamide, an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.
IPI-9119
T36841
IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).
Fasnall
T27307
Fasnall is a selective FASN inhibitor that acts through its co-factor binding sites. Fasnall shows potent anti-tumor activity in the MMTV-Neu model of HER2(+) br...
Fas C-Terminal Tripeptide Acetate
T21724L
Fas C-Terminal Tripeptide Acetate shows inhibitory activity of Fas/FAP-1 binding.
Dihydrocurcumin
T3S1701
Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and pr...
FT113
T7947
FT113 is a novel potent inhibitor of fatty acid synthase (fasn, IC50 : 213 nM),and exhibits anti-cancer activity
Isoscoparin
TN1803
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
Pseudoprotodioscin
T5S0246
1. Pseudoprotodioscin has moderate cytotoxicity.
Beta-Hydroxyisovalerylshikonin
TN1440
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
FASN-IN-3
T11557
FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
FASN-IN-1
T11267
Betulin
T3121
Betulin (lup-20(29)-ene-3β, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it forms up to 30...
VY-3-135
T9732
VY-3-135 is a metastasis inhibitor and an acetyl-​CoA synthetase 2 (ACSS2) modulator.
Lycorine
T3324
Lycorine inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
A-769662
T2468
A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
trans-C75
T10656
trans-C75 is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).
C75
T10657
C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).
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