| T1934 |
Bay 11-7085
|
196309-76-9
|
98%
|
|
|
Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
|
| T20770 |
BAY32-5915
|
1571-30-8
|
98%
|
|
|
BAY32-5915 is an inhibitor of IKKalpha.
|
| T3123 |
Allicin
|
539-86-6
|
|
|
|
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cel...
|
| T36524 |
IKK2-IN-4
|
354811-10-2
|
100%
|
|
|
IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.
|
| T6326 |
BMS-345541
|
445430-58-0
|
100%
|
|
|
BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
|
| T0167 |
Vinpocetine
|
42971-09-5
|
100%
|
|
|
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
|
| T10237 |
ACHP Hydrochloride
|
406209-26-5
|
100%
|
|
|
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.
|
| TJS1779 |
Protosappanin A
|
102036-28-2
|
100%
|
|
|
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inf...
|
| T8951 |
JTP 0819958 - HOIPIN-1
|
T8951
|
95.08%
|
|
|
JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activat...
|
| T5209 |
INH14
|
200134-22-1
|
95.41%
|
|
|
INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
|
| T1902 |
BAY 11-7082
|
19542-67-7
|
97.91%
|
|
|
BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-s...
|
| T2081 |
LY2409881 trihydrochloride
|
946518-60-1
|
98%
|
|
|
LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 and other common kinases is at least one log higher.
|
| T8705 |
BOT-64
|
113760-29-5
|
98.08%
|
|
|
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole comp...
|
| T125120 |
Cyclo(L-Pro-L-Val)
|
2854-40-2
|
98.18%
|
|
|
Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory act...
|
| T2765 |
Rosmarinic acid
|
20283-92-5
|
98.19%
|
|
|
Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and C...
|
| T1830 |
BX795
|
702675-74-9
|
98.32%
|
|
|
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
|
| T15558 |
GSK319347A
|
862812-98-4
|
98.42%
|
|
|
GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the...
|
| T5162 |
MRT67307 HCl (1190378-57-4(free base))
|
T5162
|
98.52%
|
|
|
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
|
| T7081 |
CCCP
|
555-60-2
|
98.55%
|
|
|
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the ...
|
| T22021 |
ACHP
|
406208-42-2
|
98.66%
|
|
|
ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits H...
|
