Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2].
説明 | JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2]. |
In vitro | JTP-0819958 inhibited the linear polyubiquitination activity by the HOIL-1L/HOIP complex, the HOIL-1L/HOIP/SHARPIN complex, and the HOIP/SHARPIN complex equally, with IC50 values of 4.4, 3.5, and 3.7μM. The inhibitory effects of JTP-0819958 on LUBAC-mediated linear ubiquitin generation and inflammatory cytokine-induced NF-κB activation were confirmed in cellular levels. |
分子量 | 304.27 |
分子式 | C17H13NaO4 |
CAS No. | T8951 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL(16.43 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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JTP 0819958 - HOIPIN-1 T8951 NF-Κb IκB/IKK JTP 0819958 HOIPIN1 JTP 0819958 HOIPIN 1 Inhibitor inhibitor inhibit