| T9464 |
CYM50358
|
1314212-39-9
|
98%
|
|
|
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 ...
|
| T6085 |
PF-543
|
1415562-82-1
|
98%
|
|
|
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
|
| T2000 |
AM095
|
1345614-59-6
|
98%
|
|
|
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
|
| T12086 |
Mocravimod hydrochloride
|
509088-69-1
|
98%
|
|
|
Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).
|
| T76828 |
Sonepcizumab
|
1031360-18-5
|
98%
|
Sonepcizumab
|
|
Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell...
|
| T21500 |
Sphingosine-1-phosphate
|
26993-30-6
|
98%
|
|
|
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ...
|
| T0307 |
Tyloxapol
|
25301-02-4
|
98%
|
|
|
Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.
|
| T15629 |
JTE-013
|
383150-41-2
|
|
|
|
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
|
| T7393 |
ONO-7300243
|
638132-34-0
|
|
|
|
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
|
| T6108 |
Ki16425
|
355025-24-0
|
96.15%
|
|
|
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
|
| T2026 |
CYM5442
|
1094042-01-9
|
96.65%
|
|
|
CYM5442 is an S1P agonist, targeting to Sphingosine.
|
| T3961 |
CYM-5541
|
945128-26-7
|
97.34%
|
|
|
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
|
| T6347 |
Ki16198
|
355025-13-7
|
97.6%
|
|
|
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
|
| T7360 |
GSK2018682
|
1034688-30-6
|
97.78%
|
|
|
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
|
| T6403 |
Siponimod
|
1230487-00-9
|
97.79%
|
|
|
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T...
|
| T9199 |
GLPG2938
|
2130996-00-6
|
98.1%
|
|
|
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s...
|
| T61112 |
SLF1081851
|
2763730-97-6
|
98.57%
|
|
|
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
|
| T4016 |
BMS-986020
|
1257213-50-5
|
98.61%
|
|
|
BMS-986020 (AM152) is a selective antagonist of LPA1.
|
| T22703 |
CYM-5520
|
1449747-00-5
|
98.72%
|
|
|
CYM-5520 is a noncompetitive allosteric agonist of S1P2
|
| T28169 |
NIBR-0213
|
1233332-14-3
|
98.87%
|
|
|
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
|
