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NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T10086 24-Hydroxycholesterol 30271-38-6 98%
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcripti...
T20571 Cis-PDA 46026-75-9 98%
cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.
T12536 Pregnenolone monosulfate 1247-64-9 98%
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings, and can be used in st...
T12758L Ro 25-6981 Maleate 1312991-76-6 98%
Ro 25-6981 Maleate is a selective NR2B subunit-specific NMDA receptor antagonist with anticonvulsant and antidepressant activity, which can be used in the study ...
T16451 PEAQX tetrasodium hydrate 98%
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value...
T22542 1-Aminocyclobutanecarboxylic acid 22264-50-2
1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
T5080 Spermidine trihydrochloride 334-50-9
Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride), a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-a...
T22733 DL-AP5 76326-31-3
DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects.
T1946 Felbamate 25451-15-4
Felbamate (W-554) is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activit...
T4752 1-Aminocyclopropane-1-carboxylic acid 22059-21-8
1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from ...
T25196 BZAD01 305339-41-7
BZAD01 is a selective NMDA NR1A/2B receptor antagonist.
T6259 Dizocilpine 77086-21-6
MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
T13854 Quininic acid 86-68-0 100%
Quinic acid is an organic acid extracted from the bark of Eucalyptus, Cinchona and other plants in the Asteraceae family.
T8459 DNQX disodium salt 1312992-24-7 100%
DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor
T8450 TCN 213 556803-08-8 100%
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
T10930 D-AP5 79055-68-8 100%
D-AP5 (D-APV) is a NMDA receptor antagonist.
T0030L Bupivacaine 38396-39-3 100%
Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with...
T4171 PEAQX 459836-30-7 100%
PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A...
T7867 Flutriafol 76674-21-0 100%
Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist
T16801 (RS)-(Tetrazol-5-yl)glycine 138199-51-6 95.00%
(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)gly...
24-Hydroxycholesterol
T10086
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcripti...
cis-PDA
T20571
cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.
Pregnenolone monosulfate
T12536
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings, and can be used in st...
Ro 25-6981 Maleate
T12758L
Ro 25-6981 Maleate is a selective NR2B subunit-specific NMDA receptor antagonist with anticonvulsant and antidepressant activity, which can be used in the study ...
PEAQX tetrasodium hydrate
T16451
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value...
1-Aminocyclobutanecarboxylic acid
T22542
1-Aminocyclobutanecarboxylic acid (ACBC) is a NMDA receptor partial agonist. 1-Aminocyclobutanecarboxylic acid act at the glycine site, NR1[1].
Spermidine trihydrochloride
T5080
Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride), a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-a...
DL-AP5
T22733
DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects.
Felbamate
T1946
Felbamate (W-554) is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activit...
1-Aminocyclopropane-1-carboxylic acid
T4752
1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from ...
BZAD01
T25196
BZAD01 is a selective NMDA NR1A/2B receptor antagonist.
Dizocilpine
T6259
MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.
Quininic acid
T13854
Quinic acid is an organic acid extracted from the bark of Eucalyptus, Cinchona and other plants in the Asteraceae family.
DNQX disodium salt
T8459
DNQX disodium salt is a water-soluble form of selective antagonist of non-NMDA receptor
TCN 213
T8450
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
D-AP5
T10930
D-AP5 (D-APV) is a NMDA receptor antagonist.
Bupivacaine
T0030L
Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with...
PEAQX
T4171
PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A...
Flutriafol
T7867
Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist
(RS)-(Tetrazol-5-yl)glycine
T16801
(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)gly...
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