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PKM

Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T60102L Dimethylaminomicheliolide HCl 1403357-80-1 98%
Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate ...
T72693 PKM2 activator 5 796092-26-7 98%
PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.
T0745 Disodium monofluorophosphate 10163-15-2
Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phos...
T62758 PKM2 activator 2 1186660-06-9 100%
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates th...
T8363 DL-Serine 302-84-1 98%
DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
T7214 TEPP-46 1221186-53-3 98.47%
TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation an...
T1125 Shikonin 517-89-5 98.54%
Shikonin (Anchusa acid) is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of ...
T6816 DASA-58 1203494-49-8 98.99%
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
T12499 PKR-IN-2 1628428-01-2 99.17%
PKR-IN-2 is a activator of pyruvate kinase (PKR).
T67900 PKM2 inhibitor G 904457-46-1 99.54%
PKM2 inhibitor G is a inhibitor of pyruvate kinase.
T4223 Mitapivat 1260075-17-9 99.81%
Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
T4170 PKM2-IN-1 94164-88-2 99.9%
PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
Dimethylaminomicheliolide HCl
T60102L
Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate ...
PKM2 activator 5
T72693
PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.
Disodium monofluorophosphate
T0745
Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phos...
PKM2 activator 2
T62758
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates th...
DL-Serine
T8363
DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
TEPP-46
T7214
TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation an...
Shikonin
T1125
Shikonin (Anchusa acid) is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of ...
DASA-58
T6816
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
PKR-IN-2
T12499
PKR-IN-2 is a activator of pyruvate kinase (PKR).
PKM2 inhibitor G
T67900
PKM2 inhibitor G is a inhibitor of pyruvate kinase.
Mitapivat
T4223
Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
PKM2-IN-1
T4170
PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.