Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Calpeptin is a potent, cell-permeable calpain inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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5 mg | 在庫あり | ¥ 12,000 | |||
10 mg | 在庫あり | ¥ 17,500 | |||
25 mg | 在庫あり | ¥ 37,500 | |||
50 mg | 在庫あり | ¥ 52,500 | |||
100 mg | 在庫あり | ¥ 85,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,000 |
説明 | Calpeptin is a potent, cell-permeable calpain inhibitor. |
ターゲット&IC50 | Calpain I (porcine erythrocytes):52 nM(ID50), Papainb:138 nM(ID50), Calpain II (porcine kidney):34 nM(ID50), Calpain I (human platelets):40 nM(ID50) |
In vitro | Calpeptin inhibits 20K phosphorylation in a dose-related manner in platelets stimulated by thrombin, ionomycin or collagen. [1] In differentiating PC12 cells, Calpeptin promotes neurite elongation via inhibition of Calpain activity. [2] In rat retinal ganglion cells, Calpeptin attenuates apoptosis, maintains normal whole-cell membrane potential, and thus provides functional neuroprotection. [3] |
In vivo | In a feline right ventricular (RV) PO (RVPO) model, calpeptin (0.6 mg/kg, i.v.) blocks the activation of calpain and caspase-3, cleavage of their substrates, and cardiomyocyte programmed cell death. [4] In a rat focal cerebral ischemia–reperfusion injury model, Calpeptin reduces the neuronal apoptosis in hippocampal CA1 sector via inhibition of the expression of Caspase-3. [5] |
分子量 | 362.46 |
分子式 | C20H30N2O4 |
CAS No. | 117591-20-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 67 mg/mL (184.8 mM)
DMSO: 67 mg/mL (184.8 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Calpeptin 117591-20-5 Apoptosis Proteases/Proteasome Ubiquitination Proteasome Cysteine Protease Cathepsin inhibit Inhibitor inhibitor