Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 27,000 | |||
10 mg | 在庫あり | ¥ 39,500 | |||
25 mg | 在庫あり | ¥ 59,500 | |||
50 mg | 在庫あり | ¥ 105,500 | |||
100 mg | 在庫あり | ¥ 155,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 35,500 |
説明 | RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. |
ターゲット&IC50 | HeLa cells:0.15 μM |
In vitro | Multiple myeloma (MM) lines, even those resistant to bortezomib, are sensitive to RA190 via endoplasmic reticulum stress-related apoptosis. RA190 stabilizes targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially kills HPV-transformed cells. |
In vivo | RA190 administration profoundly reduces growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment retards HPV16+ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8+ T cell responses. |
分子量 | 596.76 |
分子式 | C28H23Cl5N2O2 |
CAS No. | 1617495-03-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95mg/ml (159.19 Mm)
You can also refer to dose conversion for different animals. 詳細
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RA190 1617495-03-0 Proteases/Proteasome Ubiquitination Proteasome RA 190 inhibit RA-190 Inhibitor inhibitor