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STING

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T5516 DiABZI STING agonist-1 trihydrochloride 2138299-34-8 98%
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
T9853 STING activator Compound 53 2259624-71-8 98%
STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised ...
T10252L2 ADU-S100 ammonium salt 1638750-96-5 98%
ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemi...
T13613 ChX710 2438721-44-7 98%
ChX710 could prime the type I interferon response to cytosolic DNA, which specific cellular Interferon-Stimulated Genes (ISGs), induces the ISRE promoter sequenc...
T13015 STING agonist-4 2138300-40-8
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
T9554 SN-008 2249106-01-0 96.83%
SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
T7329 C-178 329198-87-0 98%
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells...
T9137 SN-011 2249435-90-1 98.1%
SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a dem...
T9029 STING-IN-3 2244881-69-2 98.15%
STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and ph...
T8798 MSA-2 129425-81-6 98.19%
MSA-2 is a potent and orally available non-nucleotide STING agonist.
T6273 Vadimezan 117570-53-3 98.5%
Vadimezan (NSC 640488) is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan(NSC 640488) induces the cytokines t...
T7081 CCCP 555-60-2 98.55%
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated...
T6919 Omaveloxolone 1474034-05-3 98.7%
Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
T8328 STING agonist-1 702662-50-8 98.76%
STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
T9028 STING-IN-2 346691-38-1 98.76%
STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used f...
T8655 SR-717 2375421-09-1 99.04%
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor acti...
T5154 C-176 314054-00-7 99.40%
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor
T9204 SN-001 727699-84-5 99.51%
SN-001 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease.
T5674 H-151 941987-60-6 99.52%
H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.
T60000 STING (WT/R232) activity regulator 126 702662-64-4 99.61%
STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects.
diABZI STING agonist-1 trihydrochloride
T5516
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
STING activator Compound 53
T9853
STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised ...
ADU-S100 ammonium salt
T10252L2
ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemi...
ChX710
T13613
ChX710 could prime the type I interferon response to cytosolic DNA, which specific cellular Interferon-Stimulated Genes (ISGs), induces the ISRE promoter sequenc...
STING agonist-4
T13015
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
SN-008
T9554
SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
C-178
T7329
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells...
SN-011
T9137
SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a dem...
STING-IN-3
T9029
STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and ph...
MSA-2
T8798
MSA-2 is a potent and orally available non-nucleotide STING agonist.
Vadimezan
T6273
Vadimezan (NSC 640488) is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan(NSC 640488) induces the cytokines t...
CCCP
T7081
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated...
Omaveloxolone
T6919
Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
STING agonist-1
T8328
STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
STING-IN-2
T9028
STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used f...
SR-717
T8655
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor acti...
C-176
T5154
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor
SN-001
T9204
SN-001 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease.
H-151
T5674
H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.
STING (WT/R232) activity regulator 126
T60000
STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects.
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