Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.
説明 | C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. |
In vitro | C-178 (0.01-1.25 μM) selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells. It also prevents increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs) induced by cyclic di-GMP , double-stranded DNA, and LPS when used at a concentration of 0.5 μM. |
分子量 | 322.27 |
分子式 | C17H10N2O5 |
CAS No. | 329198-87-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.22 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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C-178 329198-87-0 Immunology/Inflammation STING C178 MITA inhibit Inhibitor MPYS C 178 ERIS Stimulator of Interferon Genes TMEM173 inhibitor