Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
説明 | (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. |
ターゲット&IC50 | ER: |
In vitro | 4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. 4-HT activates on-target modification frequency for intein-Cas9 variants |
細胞研究 | Cell lines: Adult Rat and Mouse Cardiac MyocytesConcentrations: 0, 0.5, 1, 3, 5, and 10 μMIncubation Time: 15-45 minMethod:For sarcomere length measurements, cells are covered in Tyrode's containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz. |
動物実験 | Animal Models: Sprague-Dawley ratsFormulation: dissolved in 200 μl tricaprylinDosages: 21 mg/kg, 54 μmol/kgAdministration: oral administration |
別名 | Afimoxifene, 4-Hydroxytamoxifen |
分子量 | 387.51 |
分子式 | C26H29NO2 |
CAS No. | 68392-35-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 71 mg/mL (183.2 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
(E/Z)-4-Hydroxytamoxifen 68392-35-8 Endocrinology/Hormones Estrogen/progestogen Receptor Estrogen Receptor/ERR (E/Z)4Hydroxytamoxifen Inhibitor inhibit (E/Z) 4 Hydroxytamoxifen Endogenous Metabolite Afimoxifene 4-Hydroxytamoxifen inhibitor