Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 41,000 | |||
5 mg | 在庫あり | ¥ 103,500 | |||
10 mg | 在庫あり | ¥ 152,500 | |||
25 mg | 在庫あり | ¥ 226,500 | |||
50 mg | 在庫あり | ¥ 319,000 | |||
100 mg | 在庫あり | ¥ 431,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 99,500 |
説明 | (R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor. |
ターゲット&IC50 | CDK2-CyclinA:0.072 μM, CDK5-p25:0.11 μM, CDK2-CyclinE:0.041 μM, CDK7-CyclinH:1.1 μM, CDK9-CyclinT:0.18 μM, CK1δ/ε:0.4 μM, CDK1-CyclinB:0.09 μM |
In vivo | A delayed systemic post-LFP administration at 3 hours of CR8--a potent second-generation cyclin-dependent kinase (CDK) inhibitor--reduced CCA;?cortical, hippocampal, and thalamic neuronal loss;?and cortical microglial and astrocyte activation.?Furthermore, CR8 treatment attenuated sensorimotor and cognitive deficits, alleviated depressive-like symptoms, and decreased lesion volume[1]. |
別名 | (R)-CR8, (R)-Isomer, CR8 |
分子量 | 431.53 |
分子式 | C24H29N7O |
CAS No. | 294646-77-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (25.49 mM)
You can also refer to dose conversion for different animals. 詳細
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(R)-CR8 294646-77-8 Apoptosis Cell Cycle/Checkpoint CDK Inhibitor (R)CR8 caspases Cyclin dependent kinase CR-8 lesion (R)-CR8 death inhibit cell CR 8 (R)-CR-8 CR8, (R)-Isomer (R)?-?CR8 (R) CR8 Hippocampus neuroprotective (R)-Isomer CR8 Isomer PARP inhibitor