keep away from direct sunlight,store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD biosynthesis. Instead of the deamidation to nicotinic acid, nicotinamide is directly converted to β-Nicotinamide mononucleotide by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), which is a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction β-Nicotinamide mononucleotide + ATP <=> Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD. NAD is a molecule that plays a fundamental role as a cofactor in cellular redox reactions. Thus β-Nicotinamide mononucleotide is an important metabolite for the maintenance of normal NAD biosynthesis. Circulating β-Nicotinamide mononucleotide levels may play an important role in regulating cell function in physiological and pathophysiological conditions.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 7,000 | |||
10 mg | 在庫あり | ¥ 10,500 | |||
25 mg | 在庫あり | ¥ 16,500 | |||
50 mg | 在庫あり | ¥ 25,000 | |||
100 mg | 在庫あり | ¥ 35,500 | |||
500 mg | 在庫あり | ¥ 86,500 | |||
1 g | 在庫あり | ¥ 128,000 |
説明 | β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD biosynthesis. Instead of the deamidation to nicotinic acid, nicotinamide is directly converted to β-Nicotinamide mononucleotide by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), which is a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction β-Nicotinamide mononucleotide + ATP <=> Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD. NAD is a molecule that plays a fundamental role as a cofactor in cellular redox reactions. Thus β-Nicotinamide mononucleotide is an important metabolite for the maintenance of normal NAD biosynthesis. Circulating β-Nicotinamide mononucleotide levels may play an important role in regulating cell function in physiological and pathophysiological conditions. |
別名 | β-NM |
分子量 | 334.22 |
分子式 | C11H15N2O8P |
CAS No. | 1094-61-7 |
keep away from direct sunlight,store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
You can also refer to dose conversion for different animals. 詳細
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β-Nicotinamide mononucleotide 1094-61-7 Metabolism Others Endogenous Metabolite Alzheimer's inhibit obesity NMN b-NM β-NM Inhibitor intermediate diabetes NAD cardioprotection b-Nicotinamide mononucleotide cancer βNicotinamide mononucleotide β Nicotinamide mononucleotide beta-Nicotinamide mononucleotide beta-NM disease inhibitor