Powder: -20°C for 3 years | In solvent: -80°C for 1 year
11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.
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5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 15,000 | |||
25 mg | 在庫あり | ¥ 29,500 | |||
50 mg | 在庫あり | ¥ 48,000 | |||
100 mg | 在庫あり | ¥ 72,000 | |||
500 mg | 在庫あり | ¥ 173,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | 11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases. |
In vitro | 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) are assayed within the LNCaP cell line to establish that this conversion is catalyzed by the lyase activity of CYP17A1. After the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF, and 21dE are in fact metabolized to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively [2]. |
In vivo | In 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high. In congenital 11-hydroxylase deficiency and adrenal insufficiency, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very low. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism [1]. |
別名 | NSC-17102, 4-Androsten-11β-ol-3,17-dione |
分子量 | 302.41 |
分子式 | C19H26O3 |
CAS No. | 382-44-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (148.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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11-Beta-hydroxyandrostenedione 382-44-5 Metabolism Endogenous Metabolite 11Betahydroxyandrostenedione inhibit 4-androstenedione Cushing's hyperandrogenism adrenal syndrome NSC-17102 Inhibitor NSC17102 4-Androsten-11b-ol-3,17-dione 4-Androsten-11β-ol-3,17-dione 4-Androsten-11beta-ol-3,17-dione NSC 17102 steroid 11-β-hydroxyandrostenedione 11 Beta hydroxyandrostenedione 11-b-hydroxyandrostenedione 11β-hydroxylase ovarian inhibitor