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カタログ番号 | 製品名 | 別名 | ターゲット |
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T81089 | Steroid sulfatase-IN-7 | ||
Steroid sulfatase-IN-7 is an irreversible inhibitor of steroid sulfatase (STS), demonstrating potent activity with an IC50 of 0.05 nM against human placental STS, rendering it suitable for application in cancer research ... | |||
T62237 | Steroid sulfatase-IN-4 | ||
Steroid sulfatase-IN-4 (Compound 16) is an irreversible inhibitor of steroid sulfatase (STS) that acts on human STS (IC50: 25 nM). steroid sulfatase-IN-4 can be used to study endometriosis. | |||
T61212 | Steroid sulfatase-IN-2 | ||
Steroid sulfatase-IN-2 is an active inhibitor of steroid sulfatase (STS), demonstrating an IC50 value of 109.5 nM. Its potential application lies in hormone-dependent cancer research, specifically estrogen-dependent brea... | |||
T61686 | Steroid sulfatase-IN-3 | ||
Steroid sulfatase-IN-3 (compound 1q) is a highly effective Steroid sulfatase (STS) inhibitor, exhibiting an IC 50 value of 25.8 nM. This compound also demonstrates antiproliferative properties against T-47D estrogen-depe... | |||
T81091 | Steroid sulfatase-IN-5 | ||
Steroid sulfatase-IN-5 (compound 10b), an inhibitor of steroid sulfatase (STS) with an IC50 of 0.32 nM, effectively suppresses T-47D breast cancer cell proliferation, demonstrating an IC50 value of 35.7 μM. This compound... | |||
T61687 | Steroid sulfatase-IN-1 | ||
Steroid sulfatase-IN-1 is a highly potent and orally active inhibitor of the enzyme Steroid sulfatase, with an impressive IC50 value of 1.71 μM. This compound exhibits notable antitumor activity, achieving a TGI (tumor g... | |||
T81090 | Steroid sulfatase-IN-6 | ||
Steroid Sulfatase-IN-6 (Compound 10c) serves as an irreversible steroid sulfatase (STS) inhibitor, exhibiting a K i value of 0.4 nM against human placenta STS, and is applicable in tumor disease research [1]. | |||
T61979 | Steroid sulfatase/17β-HSD1-IN-4 | ||
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a potent dual inhibitor of steroid sulfatase ( STS ) and 17β-hydroxysteroid dehydrogenase type 1 ( 17β HSD1 ). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS a... | |||
T62236 | Steroid sulfatase/17β-HSD1-IN-3 | ||
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 can be used to study endometriosis and ... | |||
T61716 | Steroid sulfatase/17β-HSD1-IN-1 | ||
Steroid sulfatase/17β-HSD1-IN-1 is a highly effective inhibitor of both steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) activities, displaying an IC50 value of 28 nM against cellular human steroi... | |||
T81092 | Steroid sulfatase/17β-HSD1-IN-5 | ||
Steroid sulfatase/17β-HSD1-IN-5 serves as an irreversible inhibitor of steroid sulfatase (STS) and a reversible, selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), exhibiting IC50 values of 43 nM fo... | |||
T83752 | Biotin-SRC-1 (676–700) TFA | Biotin-Steroid Receptor Coactivator 1 (676-700) | |
Biotin-SRC-1 (676–700), a biotinylated and truncated variant of steroid receptor coactivator 1 (SRC-1), finds application in affinity-based reporter assays such as time-resolved FRET (TR-FRET) and amplified luminescent p... | |||
T0181 | Loteprednol etabonate | Lotemax,Alrex | Glucocorticoid Receptor , Antibacterial , Antibiotic |
Loteprednol etabonate (Lotemax) is an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity. | |||
T0166 | Pancuronium dibromide | Pancuronium bromide,Pavulon | AChR |
Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing ... | |||
T1531 | Mometasone furoate | Sch32088 | Glucocorticoid Receptor |
Mometasone furoate (Sch32088) is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for ski... | |||
T1167 | Cyproterone acetate | Androcur,Cyproterone 17-O-acetate | Androgen Receptor |
Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. ... | |||
T61444 | Nonsteroidal aromatase inhibitor 1 | ||
Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. Due to its potent inhibitory activity, Nonsteroidal aromatase inhibitor 1 holds promise for researc... | |||
T76147 | 3α-Hydroxysteroid dehydrogenase | ||
3α-Hydroxysteroid dehydrogenase (3α-HSD), encoded by the AKR1C4 gene, is responsible for catalyzing the transformation of 3-ketosteroids into 3α-hydroxy compounds. This enzyme significantly contributes to the inactivatio... | |||
T4464 | Irosustat | 667-Coumate,BN83495,STX64 | Others |
Irosustat (667-Coumate) is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity. | |||
T33414 | MK 0434 | MK0434,MK434,MK 434,MK-0434,MK-434 | |
MK 0434 is a steroid 5α-reductase inhibitor and hormone antagonist associated with a significant reduction in DHT. | |||
T0870 | Altrenogest | R2267,RU2267,Allyltrenbolone,A35957 | Estrogen/progestogen Receptor , Progesterone Receptor |
Altrenogest (Allyltrenbolone)(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone. | |||
T0293 | Metyrapone | NSC-25265,Su-4885 | Others , P450 , Dehydrogenase , Autophagy |
Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME. | |||
T19213 | Boldenone Cypionate | Others , Androgen Receptor | |
Boldenone Cypionate is an androgenic anabolic steroid. | |||
T83615 | S5A1 | Others | |
S5A1 is a synthetic steroid used in the study of diabetes. | |||
T6502 | Fluocinonide | Lidex,Metosyn,Topsyn | Glucocorticoid Receptor |
Fluocinonide (Topsyn) (Vanos) is an effective glucocorticoid steroid, utilized in the treatment as the skin disorders anti-inflammatory agent. | |||
T2559 | Allylestrenol | Gestanon,Gestanol,Gestanin | Estrogen/progestogen Receptor |
Allylestrenol (Gestanin) is a synthetic steroid with progestational activity. | |||
T60929 | Brassinazole | (2S,3R)-Brassinazole | Others |
Brassinazole is a selective inhibitor of triazole-type steroid (BR) biosynthesis.Brassinazole can be used to modulate the oleuropein steroid (BR) signaling pathway, which is used to regulate plant xylem growth and develo... | |||
T3137 | Boldenone Undecylenate | Parenabol,Ba 29038,Vebonol | Androgen Receptor , Endogenous Metabolite |
Boldenone Undecylenate (Parenabol) is a synthetic steroid. | |||
T21452 | Anecortave Acetate | Retaane,Al 3789,NSC 24345,NSC 15475,Anecortave | Others |
Anecortave Acetate (NSC-24345), an angiostatic steroid, is used for proteomics research. | |||
T5326 | Sugammadex sodium | Org25969,Sugammadex (sodium) | Others |
Sugammadex sodium (Org25969) , a synthetic derivative of γ-cyclodextrin, is a steroid-based neuromuscular blocker reversing agent. | |||
T27478 | GSK3987 | Liver X Receptor | |
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. | |||
T15000 | Cort108297 | Glucocorticoid Receptor | |
Cort108297 is a selective glucocorticoid receptor modulator and a selective GR antagonist with no affinity for other steroid receptors. Cort108297 showed a high affinity for GRs (Ki: 0.45nM). | |||
T2199 | Myclobutanil | Systhane | Antifungal |
Myclobutanil (Systhane) is a triazole chemical used as a fungicide. It is a steroid demethylation inhibitor, specifically inhibiting ergosterol biosynthesis. Ergosterol is a critical component of fungal cell membranes. | |||
T1594 | Vecuronium bromide | ORG NC 45 | AChR |
Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity. | |||
T0384 | Estradiol benzoate | Benzoestrofol,Benzhormovarine,Benovocylin | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. | |||
T23549 | YM 511 | P450 , Aromatase | |
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM 511 slightly ... | |||
T13684 | Equilin | 7-Dehydroestrone | Calcium Channel |
Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity that increases monocyte-endothelial adhesion through NF-κB signalling.Equilin similarly relaxes mesenteric arterial resistance by... | |||
T6503 | Fluorometholone Acetate | NSC 47438,Flarex,Eflone,Oxylone acetate | Glucocorticoid Receptor , Carbonic Anhydrase |
Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. | |||
T6215 | Abiraterone Acetate | Zytiga,CB7630 | P450 |
Abiraterone Acetate (CB7630) is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER. | |||
T6465 | Dexamethasone Sodium Phosphate | Dexadreson,Dexagro,Dalalone | IL Receptor , COX |
Dexamethasone Sodium Phosphate (Dexadreson) , an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid synthetic drugs. | |||
T67901 | SRD5A1-IN-1 | Others | |
SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 µM). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression. | |||
T3316 | Fluorometholone | Fluoromethalone,Cortilet,Oxylone,Delmeson | Glucocorticoid Receptor |
Fluorometholone (Fluoromethalone) is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic susp... | |||
T6886 | MCB-613 | MCB 613 | Src |
MCB-613 is an effective steroid receptor coactivator (SRC) stimulator. | |||
T1438 | Butoconazole nitrate | RS 35887 | Estrogen/progestogen Receptor , Antifungal |
Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversi... | |||
T0947 | Dexamethasone acetate | Dexamethasone 21-acetate,Dexamethason acetate,NSC 39471 | Glucocorticoid Receptor , Mitophagy , IL Receptor , Annexin A , NOS , Antibacterial , Autophagy |
Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexa... | |||
T60924 | Verosudil | AR-12286 | ROCK |
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-induced intraocular pressure in mice by decreasing intraocular ... | |||
T2556 | Nandrolone decanoate | 19-Nortestosterone decanoate | Others , HIV Protease |
Nandrolone decanoate (19-Nortestosterone decanoate) is the decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anabolic, and erythropoietin stimulating effects. Nandrolone enter... | |||
T28773 | SI-2 | SI2,EPH 116,EPH116,EPH-116 | Others |
SI-2 is an inhibitor (SMI) of steroid receptor coactivator-3 (SRC-3 or AIB1). SI-2 can selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells, and selectively induce breast can... | |||
T72470 | Estrone O-sulfamate | Estrone 3-O-sulfamate | Others |
Estrone O-sulfamate (Estrone 3-O-sulfamate) is a potent inhibitor of steroid sulfatase (STS). Estrone O-sulfamate is a placental microsomal inhibitor (P.M.) with IC50 values of 18 nM. Estrone O-sulfamate showed inhibitor... | |||
T9836 | (E)-SI-2 | Others | |
(E)-SI-2 is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2. It selectivel... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TN3270 | (R)-3β-Hydroxy steroid sulfotransferase-IN-11 | Others | |
(R)-3β-Hydroxy steroid sulfotransferase-IN-11 has a wide range of applications in life science related research. | |||
T5S1982 | Periplocin | Periplocoside | Apoptosis , Others |
1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato... | |||
T19470 | Nandrolone propionate | Others , Androgen Receptor | |
Nandrolone propionate is an anabolic steroid action primarily consisting of androgenic and nitrogen-retentive properties. | |||
T8709 | Nandrolone phenylpropionate | Nandrolone phenpropionate | Androgen Receptor |
Nandrolone phenylpropionate (Nandrolone phenpropionate) is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis | |||
T8117 | Metenolone acetate | Methenolone acetate | Others , Androgen Receptor |
Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure. | |||
TMA0984 | Cerevisterol | DNA/RNA Synthesis | |
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells. | |||
T2207 | Adrenosterone | 11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G | Androgen Receptor , Endogenous Metabolite |
Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex. | |||
T14001 | 11-Beta-hydroxyandrostenedione | NSC-17102,4-Androsten-11β-ol-3,17-dione | Endogenous Metabolite |
11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozyme... | |||
TN3910 | Ecdysone | Apoptosis , ATPase , Glucocorticoid Receptor , Potassium Channel , Sodium Channel , Endogenous Metabolite , Autophagy | |
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell a... | |||
T1048 | Estradiol | E2,17β-Estradiol,17β-Oestradiol,β-Estradiol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be... | |||
T36857 | Estrone sulfate sodium | Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate | Endogenous Metabolite |
Estrone sulfate sodium (17β-Estrone 3-sulfate) is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone . Estrone sulfate sodium has been investigate... | |||
T3220 | Euphorbiasteroid | Euphobiasteroid,Euphorbia factor L1 | Others , AMPK |
Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation. | |||
T8043 | 5α-Cholestane | Endogenous Metabolite | |
5α-Cholestane belongs to the cholestane steroid class of compounds. | |||
T13500 | 3-O-Acetyl-20-Hydroxyecdysone | Others | |
3-O-Acetyl-20-Hydroxyecdysone, a steroid extracted from the roots of Cyanotis arachnoidea C.B.Clark, is characterized by its unique structural modifications. | |||
TN7130 | Chlorogenin | Others | |
Chlorogenin is a natural steroid derived from the herbs of Agave americana. | |||
T7024 | Qingyangshengenin | Qingyangshengenin A,Cynanchagenin | Others |
Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents. | |||
TN1075 | Adynerin | Others | |
Adynerin is a steroid found in the herbs of Nerium oleander. | |||
T10048 | 17a-Hydroxypregnenolone | Endogenous Metabolite | |
17a-Hydroxypregnenolone is a pregnane steroid. It is a prohormone in the formation of dehydroepiandrosterone (DHEA). | |||
T20302 | Deoxycorticosterone | Desoxycorticosterone,Desoxycorticosteronum,Desoxycortone | Endogenous Metabolite |
Deoxycorticosterone (Desoxycortone) is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity. | |||
T73772 | Estrone sulfate potassium | Endogenous Metabolite | |
Estrone sulfate potassium is an estrogen ester and conjugate, a natural endogenous steroid. | |||
T2912 | Ergosterol | Provitamin D,Ergosterin,Provitamin D2 | Others , Endogenous Metabolite |
Ergosterol (Provitamin D2) is a steroid extracted from Ganoderma lucidum cystocarp. | |||
TC0026 | Testosterone benzoate | Others | |
Testosterone benzoate is a synthetic, injected anabolic androgenic steroid (AAS) and an androgen ester specifically | |||
T3130 | Testosterone phenylpropionate | Testosterone hydrocinnamate,Retandrol,Testosterone 17-phenylpropionate | Others |
Testosterone phenylpropionate (Testosterone 17-phenylpropionate)is a steroid indicated for testosterone replacement therapy in sterilization, missing testicle, hypopituitarism, and osteoporosis. | |||
T2748 | Cortodoxone | 11-Deoxycortisol,cortexolone,17α,21-dihydroxyprogesterone,Reichstein's substance S,11-Desoxycortisol | Glucocorticoid Receptor , Endogenous Metabolite |
Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland. | |||
T3S0895 | Spirostan-3-ol | Sarsaponin | Others |
Spirostan-3-ol (Sarsaponin) is a stereoisomer of Sarsasapogenin (S142505), a steroid glycoside isolated from plant materials. A saponin with with potential anti-tumor activity via apoptosis. | |||
T0856 | Dehydroisoandrosterone 3-acetate | Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,androstenolone acetate | Androgen Receptor |
Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex. | |||
T12536 | Pregnenolone monosulfate | 3β-Hydroxy-5-pregnen-20-one monosulfate | NMDAR |
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings, and can be used in studies of neuroticism and depression. | |||
TC0019 | Pregnenolone acetate | 3β-Hydroxy-5-pregnen-20-one acetate | Cannabinoid Receptor , Endogenous Metabolite |
Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of te... | |||
T2822 | Ginsenoside Rb1 | Gypenoside Ⅲ,Gypenoside III | ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV |
Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors. | |||
T6S1842 | Tenacissoside G | Tenacissimoside A | Others |
Tenacissoside G, a C21 steroid derived from the stems of Marsdenia tenacissima, can reverse multidrug resistance in cancer cells exhibiting overexpression of P-glycoprotein. | |||
T3033 | Deoxycorticosterone acetate | DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate | Glucocorticoid Receptor , Endogenous Metabolite , Adrenergic Receptor |
Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid. | |||
T4878 | Hecogenin | Hocogenin | Others , Antifungal |
Hecogenin (Hocogenin), a steroid saponin derived from Agave sisalana, serves as a specific inhibitor for human UDP-glucuronosyltransferases. Notably, it exhibits a broad range of pharmacological activities, such as anti-... | |||
T0851 | Pregnenolone | 3β-Hydroxy-5-pregnen-20-one,Arthenolone | Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel , AChR , Autophagy |
Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease. | |||
T0478 | Progesterone | Pregn-4-ene-3,20-dione | Estrogen/progestogen Receptor , Progesterone Receptor , Opioid Receptor , Endogenous Metabolite |
Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is require... | |||
T9171 | Methenolone enanthate | Others | |
Methenolone enanthate is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure. | |||
T5751 | Tigogenin | Others | |
Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis. | |||
TN7099 | Antcin A | NOD | |
antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects. | |||
T19124 | 3-Oxocholic acid | 3-Ketocholic acid | Endogenous Metabolite |
3-Oxocholic acid(3-Ketocholic acid) is the metabolite of bile acid and the main product of bile degradation by Clostridium perfringens in the intestine.3-Oxocholic acid is a steroid acid mainly found in the bile of mamma... | |||
T2733 | Sarsasapogenin | Parigenin,Sarsagenin | Apoptosis , NF-κB , Endogenous Metabolite |
Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing plants found in subtropical regions. It was one o... | |||
T7990 | 9-hydroxy-4-androstene-3,17-dione | Others | |
9-hydroxy-4-androstene-3,17-dione is a steroid hormone. It has anti-tumor activity and can inhibit the growth of many types of cancer cells, including breast, prostate and lung cancer cells. | |||
T2881 | Crustecdysone | Commisterone,B-ecdysone,Commisterone,20-Hydroxyecdysone,Ecdysterone,B-ecdysone,Hydroxyecdysone | Others , Caspase , Endogenous Metabolite , Autophagy |
Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects. | |||
T8040 | Cholesterol myristate | Cholesteryl myristate,Cholesteryl tetradecanoate | Others , Potassium Channel , GABA Receptor , Endogenous Metabolite , AChR |
Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the i... | |||
T3674 | Hydroxysafflor yellow A | HSYA,Safflomin A | TGF-beta/Smad |
Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacit... | |||
T1009 | Estrone | Oestrone,Fluoroethyl,Aquacrine | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is pr... | |||
T6654 | Saponins | Sapogenins Glycosides,Saponin | Others |
Saponins (Sapogenins Glycosides) are a mixture of triterpene and steroid saponins isolated from medicinal plants such as Aesculus hippocastanum L., Hedera helix L. and Ruscus aculeatus L., which are claimed to be effecti... | |||
T0948L | Corticosterone | 17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants) | Glucocorticoid Receptor , Endogenous Metabolite |
Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stres... | |||
T2777 | Ginsenoside Rg1 | Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,Panaxoside A,Ginsenoside A2 | Apoptosis , Beta Amyloid , NF-κB |
Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal synaptophysin level i... | |||
T1429 | 17α-Hydroxyprogesterone | Hydroxyprogesterone,17-OHP,17-Hydroxyprogesterone | Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite |
17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to th... | |||
T5574 | Guggulsterone | Guggulsterone E&Z | Apoptosis , FXR , Akt , Caspase , JNK , Autophagy |
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen. | |||
T4717 | 25-Hydroxycholesterol | Others , Endogenous Metabolite , HMG-CoA Reductase | |
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regu... | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPH-02139 | CYP17A1 Protein, Human, Recombinant (GST) | Human | E. coli |
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen sy... | |||
TMPH-02140 | CYP21A2 Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-d... | |||
TMPH-02141 | CYP21A2 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-d... | |||
TMPJ-00207 | AKR1C2 Protein, Human, Recombinant | Human | E. coli |
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation o... | |||
TMPH-00220 | Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His) | Bovine | E. coli |
Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 th... | |||
TMPH-00199 | Bet v 1-A Protein, Betula pendula, Recombinant (His & SUMO) | Betula pendula | E. coli |
May be a general steroid carrier protein. Bet v 1-A Protein, Betula pendula, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 33.4 kDa and the ac... | |||
TMPH-03654 | Vaccinia virus (strain Western Reserve) 3-beta-HSD Protein (His & Myc) | VACV | E. coli |
Catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal... | |||
TMPH-01811 | OR7D4 Protein, Human, Recombinant (His & KSI) | Human | E. coli |
Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone. OR7D4 Protein, Human, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The p... | |||
TMPJ-01076 | FKBP4 Protein, Human, Recombinant (His) | Human | E. coli |
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone recepto... | |||
TMPY-00481 | AKR1C4 Protein, Human, Recombinant (His) | Human | E. coli |
Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation ... | |||
TMPH-01747 | FDXR Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitam... | |||
TMPH-00288 | Adrenodoxin reductase Protein, Bovine, Recombinant (His) | Bovine | P. pastoris (Yeast) |
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitam... | |||
TMPH-00287 | Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His) | Bovine | E. coli |
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitam... | |||
TMPH-03128 | TSPO Protein, Pig, Recombinant (His & Myc & SUMO) | Sus scrofa (Pig) | E. coli |
Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynt... | |||
TMPH-01303 | HSD17B11 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate stero... | |||
TMPJ-00158 | Apolipoprotein A-I/APOA1 Protein, Human, Recombinant | Human | E. coli |
Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various... | |||
TMPY-00867 | Kallikrein 13/KLK13 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Tissue kallikrein 13 (hK13), also known as KLK-L4 (kallikrein-like gene 4), is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene res... | |||
TMPY-03991 | DBI Protein, Human, Recombinant (His) | Human | E. coli |
The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine rece... |
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