keep away from moisture,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis.
説明 | 3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis. |
In vitro | For 24-36 hours at concentrations ranging from 0 to 250 μM, 3'-Sialyllactose sodium promotes and restores Col2a1 synthesis, accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].In chondrocytes, 3'-Sialyllactose sodium (0-250 μM; 24 hours) activates the expression of Sox9 and inhibits NF-κB activation[3].In the presence or absence of metabolic activation, 3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect and does not exhibit evident growth inhibition and deposition in all strains[1].At a concentration of 1250 μg/mL, 3'-Sialyllactose sodium induces no chromosomal aberrations and demonstrates a non-clastogenic effect in either the presence or absence of metabolic activation[1]. |
In vivo | For 6 weeks, mice were orally administered 3'-Sialyllactose sodium at doses of 10-100 mg/kg three times a week, protecting them against cartilage destruction from osteoarthritis[3].A single oral administration of 3'-Sialyllactose sodium at doses of 500, 1000, and 2000 mg/kg induces no micronuclei in the bone marrow cells of mice[1].In male and female beagle dogs, the maximum tolerance dose (MTD) of 3'-Sialyllactose sodium, given orally at doses ranging from 500 to 1000 to 2000 mg/kg at 4-day intervals, is greater than 2000 mg/kg[3].3'-Sialyllactose sodium demonstrates a lethal dose (LD50) above 20 g/kg bw, which is the highest tested dose[1]. |
別名 | 3'-SL sodium |
分子量 | 655.53 |
分子式 | C23H38NNaO19 |
CAS No. | 128596-80-5 |
keep away from moisture,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL
H2O: 100 mg/mL (152.54 mM), Sonication is recommended.
PBS (pH 7.2): 10 mg/mL
You can also refer to dose conversion for different animals. 詳細
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3'-Sialyllactose sodium 128596-80-5 NF-Κb NF-κB 3' Sialyllactose (sodium salt) 3'Sialyllactose (sodium salt) 3'-Sialyllactose 3'-SL sodium Inhibitor inhibitor inhibit