Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans.
説明 | Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans. |
In vitro | Staphylococcus aureus (S. aureus) is responsible for difficult-to-treat and relapsing infections and constitutes one of the most problematic pathogens due to its multiple resistances to clinically available antibiotics. Additionally, the ability of S. aureus to develop small-colony variants is associated with a reduced susceptibility to aminoglycoside antibiotics and in vivo persistence. METHODS AND RESULTS: We have recently demonstrated that Tomatidine, a steroid alkaloid isolated from tomato plants, possesses anti-virulence activity against normal strains of S. aureus as well as the ability to potentiate the effect of aminoglycoside antibiotics. In addition, Tomatidine has shown antibiotic activity against small-colony variants of S. aureus. CONCLUSIONS: We herein report the first study of the structure-activity relationship of Tomatidine against S. aureus. |
植物由来 |
分子量 | 415.65 |
分子式 | C27H45NO2 |
CAS No. | 77-59-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
0.1 M HCL: < 1 mg/mL (insoluble)
DMSO: 2.86 mg/mL (6.88 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Tomatidine 77-59-8 Autophagy MAPK NF-Κb JNK NF-κB Nuclear factor-κB inhibit Nuclear factor-kappaB Inhibitor Endogenous Metabolite inhibitor