Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 39,500 | |||
5 mg | 在庫あり | ¥ 98,500 | |||
10 mg | 在庫あり | ¥ 143,000 | |||
25 mg | 在庫あり | ¥ 222,500 | |||
50 mg | 在庫あり | ¥ 294,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 99,500 |
説明 | Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα. |
ターゲット&IC50 | NF-κB:0.5 μM |
In vitro |
Eurycomalactone (ECL), an active quassinoid isolated from Eurycoma longifolia Jack, has been demonstrated to possess anticancer activity.?ECL exhibited selective cytotoxicity against the NSCLC cells A549 and COR-L23 compared to the normal lung fibroblast.?Clonogenic survival results indicated that ECL treatment prior to irradiation synergistically decreased the A549 and COR-L23 colony number.?ECL treatment reduced the expression of cyclin B1 and CDK1/2 leading to induce cell cycle arrest at the radiosensitive G /M phase.?Moreover, ECL markedly delayed the repair of radiation-induced DNA double-strand breaks (DSBs).?In A549 cells, pretreatment with ECL not only delayed the resolving of radiation-induced γ-H2AX foci but also blocked the formation of 53BP1 foci at the DSB sites.?In addition, ECL pretreatment attenuated the expression of DNA repair proteins Ku-80 and KDM4D in both NSCLC cells.?Consequently, these effects led to an increase in apoptosis in irradiated cells.?Thus, ECL radiosensitized the NSCLC cells to X-ray via G /M arrest induction and delayed the repair of X-ray-induced DSBs. It has?a great potential for ECL as an alternative safer radiosensitizer for increasing the RT efficiency against NSCLC[2]. |
植物由来 |
分子量 | 348.39 |
分子式 | C19H24O6 |
CAS No. | 23062-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (157.87 mM)
You can also refer to dose conversion for different animals. 詳細
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Eurycomalactone 23062-24-0 Microbiology/Virology NF-Κb NF-κB Anti-infection DNA double-strand protein synthesis Inhibitor Nuclear factor-kappaB Nuclear factor-κB cisplatin cyclin D1 inhibit Eurycoma longifolia Jack inhibitor