Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3-MATIDA act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro.
説明 | 3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3-MATIDA act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro. |
ターゲット&IC50 | mGluR1:6.3 μM, mGluR5:> 300 μM, GluR(AMPA):250 μM, mGluR4:> 300 μM, mGluR2:> 300 μM, NMDA:250 μM |
分子量 | 215.23 |
分子式 | C8H9NO4S |
CAS No. | 518357-51-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.15 mg/mL (10 mM), Sonication is recommended.
1eq. NaOH: 50 mM
You can also refer to dose conversion for different animals. 詳細
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3-MATIDA 518357-51-2 Neuroscience GluR NMDAR 3 MATIDA 3MATIDA Inhibitor inhibitor inhibit