Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 12,500 | |||
10 mg | 在庫あり | ¥ 20,000 | |||
25 mg | 在庫あり | ¥ 42,500 | |||
50 mg | 在庫あり | ¥ 85,000 | |||
100 mg | 在庫あり | ¥ 127,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
ターゲット&IC50 | mGluR5:30 nM(EC50) |
In vitro | VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. [1] VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. [2] |
分子量 | 305.32 |
分子式 | C17H17F2NO2 |
CAS No. | 433967-28-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 30.5 mg/mL (100 mM)
DMSO: 30.5 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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VU 0357121 433967-28-3 Neuroscience GluR inhibit Inhibitor VU-0357121 VU0357121 Metabotropic glutamate receptors mGluR inhibitor