Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 25,000 | |||
25 mg | 在庫あり | ¥ 52,500 | |||
50 mg | 在庫あり | ¥ 85,500 | |||
100 mg | 在庫あり | ¥ 137,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,500 |
説明 | 4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3) |
In vitro | 4'-BR treatment of melanoma cells resulted in (a) decrease in proliferation and clonogenic survival;?(b) induction of apoptosis accompanied by a decrease in procaspase-3, procaspase-8, and increase in the cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP);?(c) marked downregulation of proliferating cell nuclear antigen (PCNA);?and (d) inhibition of melanoma cell migration.?Further, 4'-BR caused a G0/G1 phase arrest of melanoma cells that was accompanied by an increase in WAF-1/P21 and decrease in Cyclin D1/Cyclin-dependent kinase 6 protein levels.?4'-BR causes a decrease in lactate production, glucose uptake, and NAD+ /NADH ratio.?These responses were accompanied by downregulation in lactate dehydrogenase A and glucose transporter 1 in melanoma cells.[1] |
分子量 | 291.14 |
分子式 | C14H11BrO2 |
CAS No. | 1224713-90-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (103.04 mM)
You can also refer to dose conversion for different animals. 詳細
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4'-bromo-Resveratrol 1224713-90-9 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin melanoma cell growth Apoptosis Sirtuin-3 Sirtuin-1 4' bromo Resveratrol inhibit Inhibitor cell cycle 4′‐BR 4'bromoResveratrol mitochondrial metabolic reprogramming antiproliferative inhibitor