keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 20,500 | |||
5 mg | 在庫あり | ¥ 41,000 | |||
10 mg | 在庫あり | ¥ 64,000 | |||
25 mg | 在庫あり | ¥ 109,000 | |||
50 mg | 在庫あり | ¥ 156,500 | |||
100 mg | 在庫あり | ¥ 217,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 45,500 |
説明 | 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml |
In vitro | 5-hydroxy-3?2,4?2,7-trimethoxyflavone significantly inhibited nitric oxide production and demonstrated slight reduction in prostaglandin-E2 level at tested concentrations. The production of pro-inflammatory cytokines, such as TNF-α±, IL-6, and IL-1β, were obviously reduced by 5-Hydroxy-3',4',7-trimethoxyflavone in a concentration-dependent manner. Moreover, 5-Hydroxy-3',4',7-trimethoxyflavone significantly induced reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level. In addition, we performed molecular docking and molecular dynamic simulations to study the interaction of 5-Hydroxy-3',4',7-trimethoxyflavone with inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2. Docking study showed its hydrogen bond interactions with key residues in the active site of inducible nitric oxide synthase and cyclooxygenase-2, enlightening its possible binding mode at the molecular level. The results of molecular dynamic simulations showed the stability of complexes and their interactions[1] |
植物由来 |
別名 | 5-Hydroxy-3',4',7-trimethoxyflavone |
分子量 | 328.32 |
分子式 | C18H16O6 |
CAS No. | 29080-58-8 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (27.41 mM)
You can also refer to dose conversion for different animals. 詳細
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7,3',4'-Tri-O-methylluteolin 29080-58-8 Apoptosis Immunology/Inflammation Neuroscience COX TNF Interleukin TNFR 7,3',4'TriOmethylluteolin lipopolysaccharide Tumor Necrosis Factor Receptor Inflammation-related diseases pro-inflammatory cytokines RAW 264.7 macrophage Interleukin Related inhibit TNF Receptor 5-Hydroxy-3',4',7-trimethoxyflavone Cyclooxygenase 7,3',4' Tri O methylluteolin Inhibitor inhibitor