Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and/or elongation factor 1 alpha, and is an Hsp90 regulator.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 27,500 | |||
5 mg | 在庫あり | ¥ 76,500 | |||
10 mg | 在庫あり | ¥ 114,500 | |||
25 mg | 在庫あり | ¥ 203,500 | |||
50 mg | 在庫あり | ¥ 273,500 | |||
100 mg | 在庫あり | ¥ 374,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 86,500 |
説明 | H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and/or elongation factor 1 alpha, and is an Hsp90 regulator. |
ターゲット&IC50 | MCF-7 cells:∼100 μM, ADPKD cells:5–10 μM, ErbB2:50 μM |
In vitro |
H2-Gamendazole (H2-GMZ ; 0-100 μM) was effective in rapidly blocking forskolin-induced, Cl-mediated short-circuit currents in human ADPKD cells, and it significantly inhibited both cAMP- and epidermal growth factor-induced proliferation of ADPKD cells.[1] H2-GMZ (50 μM)-treated ADPKD cells showed decreased phosphorylated ERK and decreased hyperphosphorylated retinoblastoma levels through western blot analysis.[1] H2-GMZ (50 μM ; 24、48、72 h) treatment also decreased ErbB2, Akt, and cyclin-dependent kinase 4 and it decreased levels of the cystic fibrosis transmembrane conductance regulator Cl channel protein.[1] |
In vivo | H2-Gamendazole (20 mg/kg ; intraperitoneal injections) was effective in slowing postnatal cyst formation and kidney enlargement in the ---Pkd1flox/flox: Pkhd1-Cre mouse model.[1] |
分子量 | 417.21 |
分子式 | C18H13Cl2F3N2O2 |
CAS No. | 877768-84-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (71.91 mM)
You can also refer to dose conversion for different animals. 詳細
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H2-Gamendazole 877768-84-8 Cytoskeletal Signaling Metabolism HSP Inhibitor inhibitor inhibit