Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,000 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 52,500 | |||
25 mg | 在庫あり | ¥ 106,500 | |||
50 mg | 在庫あり | ¥ 157,000 | |||
100 mg | 在庫あり | ¥ 223,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 37,500 |
説明 | YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. |
ターゲット&IC50 | GRP78:1.5 μM |
In vitro | YUM70, inhibited pancreatic cancer cell growth in vitro.YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis.?A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER. |
In vivo | YUM70 in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues.YUM70 is a novel inducer of ER stress with preclinical efficacy as a monotherapy or in combination with topoisomerase and HDAC inhibitors in pancreatic cancer. |
分子量 | 398.84 |
分子式 | C21H19ClN2O4 |
CAS No. | 423145-35-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (250.73 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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YUM70 423145-35-1 Apoptosis Cytoskeletal Signaling Endocrinology/Hormones GPCR/G Protein Metabolism HSP GPR Heat shock proteins cancer pancreatic reticulum YUM-70 GRP78 stress-mediated inhibit protein Inhibitor glucose-regulated endoplasmic YUM 70 inhibitor