keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety.
説明 | ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety. |
In vivo | In male Wistar rats, ACT-462206 (0, 10, 30, 100, 300 mg/kg; oral gavage; single dose) decreased the duration of the first non-rapid eye movement (NREM) sleep episode (60 seconds) and the first rapid eye movement (REM) sleep episode (30 seconds). Furthermore, ACT-462206 dose-dependently reduced total wake time and behavioral home cage activity, while increasing both REM and NREM sleep durations[1]. |
分子量 | 388.48 |
分子式 | C20H24N2O4S |
CAS No. | 1361321-96-1 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (205.93 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ACT-462206 1361321-96-1 GPCR/G Protein Neuroscience OX Receptor ACT462206 ACT 462206 Inhibitor inhibitor inhibit