Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
説明 | Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM). |
ターゲット&IC50 | OX receptor:< 3 nM(Ki) |
In vitro | Filorexant occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM. Filorexant demonstrated effective binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), in radioligand binding and functional cell-based assays. It has no significant off-target activities against a panel of >170 receptors and enzymes [1]. |
In vivo | Filorexant dose-dependently decreased locomotor activity and obviously enhanced sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg)[1]. |
別名 | MK-6096 |
分子量 | 420.48 |
分子式 | C24H25FN4O2 |
CAS No. | 1088991-73-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (237.82 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Filorexant 1088991-73-4 GPCR/G Protein Neuroscience OX Receptor Inhibitor inhibit MK6096 MK 6096 Orexin Receptor (OX Receptor) MK-6096 Hypocretin Receptor HCRT Receptor inhibitor