Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.
説明 | SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist. |
ターゲット&IC50 | OXB:100 nM, OXA:10 nM |
In vitro | In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. [1] |
In vivo | In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. [2] SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. [3] SB-334867 also inhibits the development of morphine analgesic tolerance in rats. [4] |
別名 | SB334867A free base, SB-334867, SB 334867, SB334867 |
分子量 | 319.32 |
分子式 | C17H13N5O2 |
CAS No. | 792173-99-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 3.2 mg/mL (10 mM)), Heating is recommended.
DMSO: 31.9 mg/mL (100 mM), Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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SB-334867 free base 792173-99-0 GPCR/G Protein Neuroscience OX Receptor CHO SB334867A free base BEC ethanol intake SB-334867 SB334867 free base sucrose Hypocretin Receptor locomotor cell SB 334867 activity SB334867A SB334867 Orexin Receptor (OX Receptor) SB 334867 free base HCRT Receptor inhibit Inhibitor inhibitor