Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
説明 | IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. |
ターゲット&IC50 | OX2:7.85 (pKi) , OX1:6.29 (pKi) |
In vitro | BBAC or the selective OX2R antagonist IPSU bind rapidly and reach equilibrium very quickly in binding and/or functional assays[1]. |
In vivo | IPSU?exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration.?IPSU increases sleep when dosed during the mouse active phase (lights off);?IPSU induces sleep primarily by increasing NREM sleep.?IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing.?The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day[2] |
分子量 | 405.49 |
分子式 | C23H27N5O2 |
CAS No. | 1373765-19-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (73.98 mM)
You can also refer to dose conversion for different animals. 詳細
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IPSU 1373765-19-5 GPCR/G Protein Neuroscience OX Receptor inhibit HCRT Receptor Hypocretin Receptor Orexin Receptor (OX Receptor) Inhibitor inhibitor