Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
説明 | ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo. |
In vivo | ASP7663, a novel and selective TRPA1 agonist, in constipation models as well as an abdominal pain model.?ASP7663 activated human, rat, and mouse TRPA1 and released 5-HT from QGP-1 cells, and oral but not intravenous administration of ASP7663 significantly improved the loperamide-induced delay in colonic transit in mice.?While pretreatment with the TRPA1 antagonist HC-030031 and vagotomy both inhibited the ameliorating effect of oral ASP7663 on the colonic transit, both orally and intravenously administered ASP7663 significantly inhibited colorectal distension (CRD)-induced abdominal pain response in rats[1]. |
分子量 | 263.26 |
分子式 | C14H14FNO3 |
CAS No. | 1190217-35-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (41.78 mM)
You can also refer to dose conversion for different animals. 詳細
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ASP7663 1190217-35-6 Membrane transporter/Ion channel TRP/TRPV Channel pain inhibit TRP Channel Transient receptor potential channels Inhibitor ASP 7663 ASP-7663 inhibitor