Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 16,500 | |||
25 mg | 在庫あり | ¥ 32,000 | |||
50 mg | 在庫あり | ¥ 45,500 | |||
100 mg | 在庫あり | ¥ 68,500 | |||
200 mg | 在庫あり | ¥ 104,500 | |||
500 mg | お問い合わせ | ¥ 169,000 |
説明 | Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM). |
ターゲット&IC50 | TRPM3:0.3 μM |
In vitro | Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones[1]. |
In vivo | Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms[2]. |
別名 | 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone |
分子量 | 258.27 |
分子式 | C15H14O4 |
CAS No. | 487-49-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (212.96 mM)
Ethanol: < 30 mg/mL (116.16 mM)
You can also refer to dose conversion for different animals. 詳細
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Ononetin 487-49-0 Membrane transporter/Ion channel TRP/TRPV Channel Inhibitor Transient receptor potential channels inhibit Ca2+ TRP Channel 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone TRPM3 deoxybenzoin inhibitor