Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).
説明 | GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively). |
ターゲット&IC50 | TRPC5 (rat):0.18 μM , TRPC4 (human):0.29 μM , TRPC5 (human):0.18 μM |
In vitro | GFB-8438 is a novel TRPC5 inhibitor. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate (PS) in vitro. |
In vivo | GFB-8438is also efficacious in a hypertensive deoxycorticosterone acetate (DOCA)-salt rat model of FSGS, significantly reducing both total protein and albumin concentrations in urine |
動物実験 | Sprague Dawley rats (DOCA-salt rat model of FSGS);30 mg/kg; Administration:s.c.; daily for 3 weeks |
分子量 | 386.76 |
分子式 | C16H14ClF3N4O2 |
CAS No. | 2304549-73-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (71.1 mM)
You can also refer to dose conversion for different animals. 詳細
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GFB-8438 2304549-73-1 Membrane transporter/Ion channel TRP/TRPV Channel mouse selective Transient receptor potential channels Inhibitor inhibit remodeling TRP Channel deoxycorticosterone loss subtype cytoskeletal GFB 8438 synaptopodin podocytes GFB8438 kidney disease acetate inhibitor