Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.
説明 | AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation. |
ターゲット&IC50 | P2X7:11.2 nM |
In vitro | The antagonist AZD9056 blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line, indicating a high selectivity of the antagonist for the P2X7 receptor.The P2X7-receptor antagonist AZD9056 has a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells[1]. |
In vivo | Treatment with AZD9056 demonstrates analgesic and anti-inflammatory properties by reversing the MIA-induced upregulation of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) in cartilage tissues. |
分子量 | 455.46 |
分子式 | C24H36Cl2N2O2 |
CAS No. | 345303-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL (105.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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AZD9056 hydrochloride 345303-91-5 Membrane transporter/Ion channel Neuroscience P2X Receptor AZD 9056 Hydrochloride AZD 9056 AZD-9056 AZD9056 Hydrochloride P2XRs Inhibitor AZD-9056 Hydrochloride AZD-9056 hydrochloride AZD9056 inhibit inhibitor