keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic
説明 | Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic |
In vivo | Alagebrium treatment in diabetic rats significantly inhibits neointimal hyperplasia after carotid balloon injury due to its inhibition of intracellular ROS synthesis, which results in inhibition of RASMCs proliferation[1]. |
動物実験 | Rat aortic vascular smooth muscle cells (RASMCs) were treated with 1-100 μM of alagebrium added 24 hours before the addition of AGEs.?This in vivo study was done using 8-week-old male rats that were injected intraperitoneally with 80 mg/kg STZ.?Sixteen weeks later, the diabetic rats were treated with 10 mg/kg alagebrium for 4 weeks, after which carotid artery balloon injury was induced.?After 4 weeks, the animals were sacrificed for histological analysis[1]. |
別名 | ALT711 |
分子量 | 267.77 |
分子式 | C13H14ClNOS |
CAS No. | 341028-37-3 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (93.36 mM)
You can also refer to dose conversion for different animals. 詳細
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Alagebrium chloride 341028-37-3 Metabolism Others Endogenous Metabolite ALT711 ALT-711 Inhibitor inhibit Alagebrium Alagebrium Chloride ALT 711 inhibitor