Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 11,500 | |||
5 mg | 在庫あり | ¥ 21,500 | |||
10 mg | 在庫あり | ¥ 31,000 | |||
25 mg | 在庫あり | ¥ 52,000 | |||
50 mg | 在庫あり | ¥ 81,500 | |||
100 mg | 在庫あり | ¥ 134,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,000 |
説明 | Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance. |
ターゲット&IC50 | Abacavir resistant:32 μM, Wild-type (control):25 μM, Zidovudine-resistant:30 μM, Lamivudine-resistant:21 μM, HIV-1 (IIIB):20 μM, Zidovudine-resistant/lamivudine-resistant:55 μM |
別名 | AVX754, SPD754 |
分子量 | 229.26 |
分子式 | C8H11N3O3S |
CAS No. | 160707-69-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (47.98 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Apricitabine 160707-69-7 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Proteases/Proteasome HIV Protease DNA/RNA Synthesis SPD-754 AVX754 SPD 754 SPD754 AVX 754 AVX-754 Inhibitor inhibitor inhibit