Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 8,500 | |||
50 mg | 在庫あり | ¥ 12,000 | |||
100 mg | 在庫あり | ¥ 18,500 | |||
200 mg | 在庫あり | ¥ 29,000 | |||
500 mg | 在庫あり | ¥ 50,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis. |
In vivo | Azithromycin (50 mg/kg) does not alter bronchoalveolar lavage inflammatory parameters or LDH levels in a mouse asthma exacerbation model. It also does not induce general inflammation or LDH release, but enhances interferon-stimulated gene expression and MDA5, a pattern recognition receptor, effectively lowering viral load without affecting RIG-I in exacerbating mice[2]. |
細胞研究 | THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm. |
別名 | CP-62993 dihydrate, Azithromycin dihydrate |
分子量 | 785.03 |
分子式 | C38H72N2O12·2H2O |
CAS No. | 117772-70-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mg/mL (12.73 mM)
DMSO: 50 mg/mL (63.69 mM)
Ethanol: 93 mg/mL (118.5 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Azithromycin hydrate 117772-70-0 Autophagy Microbiology/Virology ribosome Antibiotic Antibacterial CP 62993 Dihydrate inhibit CP-62993 CP-62993 dihydrate Azithromycin Dihydrate Azithromycin Hydrate Azithromycin dihydrate Bacterial CP-62993 Dihydrate Inhibitor CP62993 Azithromycin CP 62993 CP62993 Dihydrate inhibitor